Term Information [More information on neuromuscular junction]

Accession
GO:0031594
Name
neuromuscular junction
Ontology
cellular_component
Synonyms
NMJ, motor endplate
Definition
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. Source: GOC:nln
Comment
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
History
See term history for GO:0031594 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0031594 from QuickGO

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Ancestors of neuromuscular junction (GO:0031594)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neuromuscular junction [Inferred is_a relation] is_a (inferred) cellular_component (GO:0005575)
neuromuscular junction [is_a relation] is_a  synapse (GO:0045202)
Children of neuromuscular junction (GO:0031594)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
excitatory neuromuscular junction (GO:0098520) [is_a relation] is_a  neuromuscular junction
inhibitory neuromuscular junction (GO:0098521) [is_a relation] is_a  neuromuscular junction
neuromuscular junction of myotube (GO:0098523) [is_a relation] is_a  neuromuscular junction
neuromuscular junction of somatic muscle (GO:0098527) [is_a relation] is_a  neuromuscular junction
NIF_Subcellular
sao1124888485
Wikipedia
Neuromuscular_junction