Term Information [More information on death-inducing signaling complex]

Accession
GO:0031264
Name
death-inducing signaling complex
Ontology
cellular_component
Synonyms
DISC, DISC protein complex, death receptor-induced signaling complex, death receptor-induced signalling complex, death-inducing signalling complex
Definition
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. Source: PMID:12655293, GOC:mtg_apoptosis, PMID:12628743, PMID:8521815
Comment
Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
History
See term history for GO:0031264 at QuickGO
Subset
goslim_pir
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
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Graph of GO:0031264 from QuickGO

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Ancestors of death-inducing signaling complex (GO:0031264)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) cell periphery (GO:0071944)
death-inducing signaling complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) membrane (GO:0016020)
death-inducing signaling complex [Inferred is_a relation] is_a (inferred) membrane part (GO:0044425)
death-inducing signaling complex [Inferred part_of relation] part_of (inferred) plasma membrane (GO:0005886)
death-inducing signaling complex [is_a relation] is_a  protein complex (GO:0043234)
death-inducing signaling complex [Inferred is_a relation] is_a (inferred) membrane protein complex (GO:0098796)
death-inducing signaling complex [is_a relation] is_a  plasma membrane part (GO:0044459)
death-inducing signaling complex [is_a relation] is_a  plasma membrane protein complex (GO:0098797)
Children of death-inducing signaling complex (GO:0031264)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CD95 death-inducing signaling complex (GO:0031265) [is_a relation] is_a  death-inducing signaling complex
TRAIL death-inducing signaling complex (GO:0031266) [is_a relation] is_a  death-inducing signaling complex