AmiGO 2: Term Details for "endoplasmic reticulum unfolded protein response" (GO:0030968)

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Term Information

Accession: GO:0030968
Name: endoplasmic reticulum unfolded protein response
Ontology: biological_process
Synonyms: ER unfolded protein response, erUPR, SREBP-mediated signalling pathway
Alternate IDs: None
Definition: The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. Source: PMID:12042763, GOC:mah
Comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'.
History: See term history for GO:0030968 at QuickGO
Subset: None
Related: Link to all genes and gene products annotated to endoplasmic reticulum unfolded protein response.; Link to all direct and indirect annotations to endoplasmic reticulum unfolded protein response.; Link to all direct and indirect annotations download (limited to first 10,000) for endoplasmic reticulum unfolded protein response.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
GO:0042221 response to chemical
GO:0065007 biological regulation
GO:0070887 cellular response to chemical stimulus
GO:0010033 response to organic substance
GO:0006950 response to stress
GO:0071310 cellular response to organic substance
GO:0033554 cellular response to stress
GO:0050789 regulation of biological process
GO:0035966 response to topologically incorrect protein
GO:0023052 signaling
GO:0044699 single-organism process
GO:0007154 cell communication
GO:0035967 cellular response to topologically incorrect protein
GO:0050794 regulation of cellular process
GO:0006986 response to unfolded protein
GO:0044700 single organism signaling
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0007165 signal transduction
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0036498 IRE1-mediated unfolded protein response
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:0036499 PERK-mediated unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:1900101 regulation of endoplasmic reticulum unfolded protein response

Parents of endoplasmic reticulum unfolded protein response (GO:0030968)

subject	relation	object
endoplasmic reticulum unfolded protein response	part_of	cellular response to unfolded protein (GO:0034620)
endoplasmic reticulum unfolded protein response	is_a	response to endoplasmic reticulum stress (GO:0034976)
endoplasmic reticulum unfolded protein response	is_a	signal transduction (GO:0007165)

Children of endoplasmic reticulum unfolded protein response (GO:0030968)

subject	relation	object
negative regulation of endoplasmic reticulum unfolded protein response (GO:1900102)	negatively_regulates	endoplasmic reticulum unfolded protein response
activation of signaling protein activity involved in unfolded protein response (GO:0006987)	part_of	endoplasmic reticulum unfolded protein response
ATF6-mediated unfolded protein response (GO:0036500)	is_a	endoplasmic reticulum unfolded protein response
regulation of endoplasmic reticulum unfolded protein response (GO:1900101)	regulates	endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response (GO:0036498)	is_a	endoplasmic reticulum unfolded protein response
positive regulation of endoplasmic reticulum unfolded protein response (GO:1900103)	positively_regulates	endoplasmic reticulum unfolded protein response
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response (GO:0006990)	part_of	endoplasmic reticulum unfolded protein response
PERK-mediated unfolded protein response (GO:0036499)	is_a	endoplasmic reticulum unfolded protein response

Reactome: REACT_94656; REACT_18356; REACT_88034; REACT_102268; REACT_92132; REACT_104319; REACT_84351; REACT_76959; REACT_29195; REACT_89826; REACT_86876; REACT_84686; REACT_32369; REACT_33997; REACT_79574; REACT_34742; REACT_93381