Term Information [More information on beta-catenin destruction complex]

Accession
GO:0030877
Name
beta-catenin destruction complex
Ontology
cellular_component
Synonyms
alt. id: GO:0034747, GO:0034742
APC-Axin-1-beta-catenin complex, Axin-APC-beta-catenin-GSK3B complex, BDC, beta-catenin degradation complex, 23S APC complex
Definition
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. Source: PMID:14600025
Comment
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
History
See term history for GO:0030877 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0030877 from QuickGO

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Ancestors of beta-catenin destruction complex (GO:0030877)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
beta-catenin destruction complex [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
beta-catenin destruction complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
beta-catenin destruction complex [is_a relation] is_a  cytoplasmic part (GO:0044444)
beta-catenin destruction complex [is_a relation] is_a  protein complex (GO:0043234)

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