AmiGO 2: Term Details for "ubiquitin-dependent ERAD pathway" (GO:0030433)

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Term Information

Accession: GO:0030433
Name: ubiquitin-dependent ERAD pathway
Ontology: biological_process
Synonyms: ER-associated ubiquitin-dependent protein breakdown, ER-associated ubiquitin-dependent protein catabolic process, ER-associated ubiquitin-dependent protein catabolism, ER-associated ubiquitin-dependent protein degradation, endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process, endoplasmic reticulum-associated ubiqutin-dependent protein catabolism, ubiquitin-dependent proteasomal protein catabolism of ER proteins, ERAD
Alternate IDs: None
Definition: The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Source: PMID:19520858, PMID:14607247, GOC:rb, GOC:mah
Comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
History: See term history for GO:0030433 at QuickGO
Subset: None
Related: Link to all genes and gene products annotated to ubiquitin-dependent ERAD pathway.; Link to all direct and indirect annotations to ubiquitin-dependent ERAD pathway.; Link to all direct and indirect annotations download (limited to first 10,000) for ubiquitin-dependent ERAD pathway.

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009056 catabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0044237 cellular metabolic process
GO:0043170 macromolecule metabolic process
GO:1901575 organic substance catabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0044248 cellular catabolic process
GO:0044260 cellular macromolecule metabolic process
GO:0009057 macromolecule catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:0019538 protein metabolic process
GO:0044265 cellular macromolecule catabolic process
GO:0044267 cellular protein metabolic process
GO:0030163 protein catabolic process
GO:0044257 cellular protein catabolic process
GO:0006508 proteolysis
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
GO:0043632 modification-dependent macromolecule catabolic process
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0042221 response to chemical
GO:0006950 response to stress
GO:0044699 single-organism process
GO:0033554 cellular response to stress
GO:0019941 modification-dependent protein catabolic process
GO:1901698 response to nitrogen compound
GO:0010033 response to organic substance
GO:0044710 single-organism metabolic process
GO:0010498 proteasomal protein catabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0010243 response to organonitrogen compound
GO:0044712 single-organism catabolic process
GO:0044763 single-organism cellular process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030433 ubiquitin-dependent ERAD pathway
GO:1990389 CUE1-UBC7 ubiquitin-conjugating enzyme complex
GO:0000837 Doa10p ubiquitin ligase complex
GO:0000835 ER ubiquitin ligase complex
GO:0000836 Hrd1p ubiquitin ligase complex
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway
GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway

Parents of ubiquitin-dependent ERAD pathway (GO:0030433)

subject	relation	object
ubiquitin-dependent ERAD pathway	is_a	ERAD pathway (GO:0036503)
ubiquitin-dependent ERAD pathway	is_a	proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

Children of ubiquitin-dependent ERAD pathway (GO:0030433)

subject	relation	object
ubiquitin protein ligase activity involved in ERAD pathway (GO:1904264)	part_of	ubiquitin-dependent ERAD pathway
positive regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903071)	positively_regulates	ubiquitin-dependent ERAD pathway
Hrd1p ubiquitin ligase complex (GO:0000836)	capable_of_part_of	ubiquitin-dependent ERAD pathway
ubiquitin-dependent glycoprotein ERAD pathway (GO:0097466)	is_a	ubiquitin-dependent ERAD pathway
regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903069)	regulates	ubiquitin-dependent ERAD pathway
Doa10p ubiquitin ligase complex (GO:0000837)	capable_of_part_of	ubiquitin-dependent ERAD pathway
Hrd1p ubiquitin ligase ERAD-M complex (GO:0000838)	capable_of_part_of	ubiquitin-dependent ERAD pathway
Hrd1p ubiquitin ligase ERAD-L complex (GO:0000839)	capable_of_part_of	ubiquitin-dependent ERAD pathway
CUE1-UBC7 ubiquitin-conjugating enzyme complex (GO:1990389)	capable_of_part_of	ubiquitin-dependent ERAD pathway
ER ubiquitin ligase complex (GO:0000835)	capable_of_part_of	ubiquitin-dependent ERAD pathway
negative regulation of ER-associated ubiquitin-dependent protein catabolic process (GO:1903070)	negatively_regulates	ubiquitin-dependent ERAD pathway

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