Term Information [More information on reductive tricarboxylic acid cycle]

Accession
GO:0019643
Name
reductive tricarboxylic acid cycle
Ontology
biological_process
Synonyms
alt. id: GO:0019644
reductive Kreb's cycle, reductive TCA cycle, reductive carboxylate cycle, reductive carboxylic acid cycle, reductive citric acid pathway
Definition
A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. Source: PMID:15838028, GOC:jl
Comment
None
History
See term history for GO:0019643 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0019643 from QuickGO

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Ancestors of reductive tricarboxylic acid cycle (GO:0019643)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) single-organism metabolic process (GO:0044710)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) cellular metabolic process (GO:0044237)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) small molecule metabolic process (GO:0044281)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) organic acid metabolic process (GO:0006082)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) generation of precursor metabolites and energy (GO:0006091)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) oxidation-reduction process (GO:0055114)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) oxoacid metabolic process (GO:0043436)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) carboxylic acid metabolic process (GO:0019752)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) energy derivation by oxidation of organic compounds (GO:0015980)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) cellular respiration (GO:0045333)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) tricarboxylic acid metabolic process (GO:0072350)
reductive tricarboxylic acid cycle [Inferred part_of relation] part_of (inferred) aerobic respiration (GO:0009060)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) citrate metabolic process (GO:0006101)
reductive tricarboxylic acid cycle [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
reductive tricarboxylic acid cycle [is_a relation] is_a  carbon fixation (GO:0015977)
reductive tricarboxylic acid cycle [is_a relation] is_a  tricarboxylic acid cycle (GO:0006099)

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MetaCyc
P23-PWY
REDCITCYC