Term Information [More information on NMDA selective glutamate receptor complex]

Accession
GO:0017146
Name
NMDA selective glutamate receptor complex
Ontology
cellular_component
Synonyms
N-methyl-D-aspartate selective glutamate receptor complex, NMDA-selective glutamate receptor
Definition
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. Source: http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html
Comment
None
History
See term history for GO:0017146 at QuickGO
Subset
None
Community
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Feedback
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Contacting server...
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Graph of GO:0017146 from QuickGO

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Ancestors of NMDA selective glutamate receptor complex (GO:0017146)
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NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) localization (GO:0051179)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular process (GO:0009987)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) establishment of localization (GO:0051234)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism process (GO:0044699)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) signaling (GO:0023052)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism cellular process (GO:0044763)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism localization (GO:1902578)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transport (GO:0006810)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) biological regulation (GO:0065007)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cell communication (GO:0007154)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) molecular_function (GO:0003674)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) single organism signaling (GO:0044700)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism transport (GO:0044765)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) cell periphery (GO:0071944)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cell-cell signaling (GO:0007267)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) membrane (GO:0016020)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of biological process (GO:0050789)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) response to stimulus (GO:0050896)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transmembrane transport (GO:0055085)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) transporter activity (GO:0005215)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular response to stimulus (GO:0051716)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) membrane part (GO:0044425)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) plasma membrane (GO:0005886)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular process (GO:0050794)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) synaptic signaling (GO:0099536)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transmembrane transporter activity (GO:0022857)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) whole membrane (GO:0098805)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ion transport (GO:0006811)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) membrane region (GO:0098589)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) molecular transducer activity (GO:0060089)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) passive transmembrane transporter activity (GO:0022803)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) plasma membrane part (GO:0044459)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) signal transduction (GO:0007165)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) substrate-specific transporter activity (GO:0022892)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) synapse (GO:0045202)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) trans-synaptic signaling (GO:0099537)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) anterograde trans-synaptic signaling (GO:0098916)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cell surface receptor signaling pathway (GO:0007166)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) channel activity (GO:0015267)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ion transmembrane transport (GO:0034220)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) plasma membrane region (GO:0098590)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) receptor activity (GO:0004872)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) substrate-specific transmembrane transporter activity (GO:0022891)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) synapse part (GO:0044456)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) gated channel activity (GO:0022836)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ion transmembrane transporter activity (GO:0015075)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) postsynapse (GO:0098794)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) signal transducer activity (GO:0004871)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) substrate-specific channel activity (GO:0022838)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) synaptic membrane (GO:0097060)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) synaptic transmission (GO:0007268)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transmembrane receptor activity (GO:0099600)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) chemical synaptic transmission, postsynaptic (GO:0099565)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ion channel activity (GO:0005216)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) ligand-gated channel activity (GO:0022834)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
NMDA selective glutamate receptor complex [Inferred related_to relation] related_to (inferred) postsynaptic membrane (GO:0045211)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) signaling receptor activity (GO:0038023)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) intrinsic component of membrane (GO:0031224)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) ligand-gated ion channel activity (GO:0015276)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) neurotransmitter receptor activity (GO:0030594)
NMDA selective glutamate receptor complex [is_a relation] is_a  protein complex (GO:0043234)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transmembrane signaling receptor activity (GO:0004888)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) extracellular ligand-gated ion channel activity (GO:0005230)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) glutamate receptor signaling pathway (GO:0007215)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) integral component of membrane (GO:0016021)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) membrane protein complex (GO:0098796)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) transmitter-gated channel activity (GO:0022835)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) transporter complex (GO:1990351)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) glutamate receptor activity (GO:0008066)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) intrinsic component of plasma membrane (GO:0031226)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ionotropic glutamate receptor signaling pathway (GO:0035235)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) plasma membrane protein complex (GO:0098797)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) receptor complex (GO:0043235)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) transmembrane transporter complex (GO:1902495)
NMDA selective glutamate receptor complex [Inferred capable_of relation] capable_of (inferred) transmitter-gated ion channel activity (GO:0022824)
NMDA selective glutamate receptor complex [Inferred part_of relation] part_of (inferred) integral component of plasma membrane (GO:0005887)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) ion channel complex (GO:0034702)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) ionotropic glutamate receptor activity (GO:0004970)
NMDA selective glutamate receptor complex [Inferred is_a relation] is_a (inferred) plasma membrane receptor complex (GO:0098802)
NMDA selective glutamate receptor complex [is_a relation] is_a  ionotropic glutamate receptor complex (GO:0008328)
NMDA selective glutamate receptor complex [Inferred capable_of part of relation] capable_of part of (inferred) NMDA glutamate receptor activity (GO:0004972)

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