Term Information [More information on mediator complex]

Accession
GO:0016592
Name
mediator complex
Ontology
cellular_component
Synonyms
alt. id: GO:0000119
L mediator complex, Srb-mediator complex, CDK8-containing TRAP/mediator complex, TRAP complex
Definition
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:11454195, PMID:16168358, PMID:17870225
Comment
None
History
See term history for GO:0016592 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0016592 from QuickGO

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Ancestors of mediator complex (GO:0016592)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mediator complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
mediator complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
mediator complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
mediator complex [Inferred part_of relation] part_of (inferred) organelle (GO:0043226)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle (GO:0043229)
mediator complex [Inferred part_of relation] part_of (inferred) membrane-bounded organelle (GO:0043227)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular membrane-bounded organelle (GO:0043231)
mediator complex [Inferred part_of relation] part_of (inferred) membrane-enclosed lumen (GO:0031974)
mediator complex [Inferred part_of relation] part_of (inferred) organelle part (GO:0044422)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle part (GO:0044446)
mediator complex [Inferred part_of relation] part_of (inferred) nucleus (GO:0005634)
mediator complex [Inferred part_of relation] part_of (inferred) organelle lumen (GO:0043233)
mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle lumen (GO:0070013)
mediator complex [Inferred part_of relation] part_of (inferred) nuclear part (GO:0044428)
mediator complex [Inferred part_of relation] part_of (inferred) nuclear lumen (GO:0031981)
mediator complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
mediator complex [Inferred part_of relation] part_of (inferred) nucleoplasm (GO:0005654)
mediator complex [is_a relation] is_a  nucleoplasm part (GO:0044451)
mediator complex [is_a relation] is_a  protein complex (GO:0043234)

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