Term Information [More information on gene silencing]

Accession
GO:0016458
Name
gene silencing
Ontology
biological_process
Synonyms
long-term maintenance of gene inactivation
Definition
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. Source: GOC:dph, GOC:dos, GOC:jid, GOC:tb
Comment
This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class.
History
See term history for GO:0016458 at QuickGO
Subset
goslim_pir
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
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Contacting server...
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Graph of GO:0016458 from QuickGO

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Ancestors of gene silencing (GO:0016458)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gene silencing [Inferred negatively_regulates relation] negatively_regulates (inferred) biological_process (GO:0008150)
gene silencing [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
gene silencing [Inferred negatively_regulates relation] negatively_regulates (inferred) metabolic process (GO:0008152)
gene silencing [Inferred negatively_regulates relation] negatively_regulates (inferred) organic substance metabolic process (GO:0071704)
gene silencing [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
gene silencing [Inferred negatively_regulates relation] negatively_regulates (inferred) macromolecule metabolic process (GO:0043170)
gene silencing [Inferred is_a relation] is_a (inferred) negative regulation of biological process (GO:0048519)
gene silencing [Inferred is_a relation] is_a (inferred) regulation of metabolic process (GO:0019222)
gene silencing [Inferred negatively_regulates relation] negatively_regulates (inferred) gene expression (GO:0010467)
gene silencing [Inferred is_a relation] is_a (inferred) negative regulation of metabolic process (GO:0009892)
gene silencing [Inferred is_a relation] is_a (inferred) regulation of macromolecule metabolic process (GO:0060255)
gene silencing [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
gene silencing [Inferred is_a relation] is_a (inferred) negative regulation of macromolecule metabolic process (GO:0010605)
gene silencing [Inferred is_a relation] is_a (inferred) regulation of gene expression (GO:0010468)
gene silencing [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
gene silencing [is_a relation] is_a  negative regulation of gene expression (GO:0010629)
gene silencing [is_a relation] is_a  single-organism cellular process (GO:0044763)
Children of gene silencing (GO:0016458)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
chromatin silencing (GO:0006342) [is_a relation] is_a  gene silencing
gene silencing by RNA (GO:0031047) [is_a relation] is_a  gene silencing
gene silencing involved in chronological cell aging (GO:0010978) [is_a relation] is_a  gene silencing
mRNA cleavage involved in gene silencing (GO:0098795) [part_of relation] part_of  gene silencing
negative regulation of gene silencing (GO:0060969) [negatively_regulates relation] negatively_regulates  gene silencing
posttranscriptional gene silencing (GO:0016441) [is_a relation] is_a  gene silencing
regulation of gene silencing (GO:0060968) [regulates relation] regulates  gene silencing
Wikipedia
Gene_silencing