Term Information [More information on RNA interference]

Accession
GO:0016246
Name
RNA interference
Ontology
biological_process
Synonyms
RNAi, posttranscriptional gene silencing by siRNA
Definition
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. Source: GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919
Comment
Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
History
See term history for GO:0016246 at QuickGO
Subset
None
Community
GN View or edit usage comments for this term on the GONUTS wiki.
Feedback
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View this term in QuickGO.

Graph of GO:0016246 from QuickGO

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Ancestors of RNA interference (GO:0016246)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA interference [Inferred negatively_regulates relation] negatively_regulates (inferred) biological_process (GO:0008150)
RNA interference [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
RNA interference [Inferred negatively_regulates relation] negatively_regulates (inferred) metabolic process (GO:0008152)
RNA interference [Inferred negatively_regulates relation] negatively_regulates (inferred) organic substance metabolic process (GO:0071704)
RNA interference [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
RNA interference [Inferred negatively_regulates relation] negatively_regulates (inferred) macromolecule metabolic process (GO:0043170)
RNA interference [Inferred is_a relation] is_a (inferred) negative regulation of biological process (GO:0048519)
RNA interference [Inferred is_a relation] is_a (inferred) regulation of metabolic process (GO:0019222)
RNA interference [Inferred negatively_regulates relation] negatively_regulates (inferred) gene expression (GO:0010467)
RNA interference [Inferred is_a relation] is_a (inferred) negative regulation of metabolic process (GO:0009892)
RNA interference [Inferred is_a relation] is_a (inferred) regulation of macromolecule metabolic process (GO:0060255)
RNA interference [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
RNA interference [Inferred is_a relation] is_a (inferred) negative regulation of macromolecule metabolic process (GO:0010605)
RNA interference [Inferred is_a relation] is_a (inferred) regulation of gene expression (GO:0010468)
RNA interference [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
RNA interference [Inferred is_a relation] is_a (inferred) negative regulation of gene expression (GO:0010629)
RNA interference [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
RNA interference [Inferred is_a relation] is_a (inferred) gene silencing (GO:0016458)
RNA interference [Inferred is_a relation] is_a (inferred) posttranscriptional regulation of gene expression (GO:0010608)
RNA interference [Inferred is_a relation] is_a (inferred) regulation of gene expression, epigenetic (GO:0040029)
RNA interference [Inferred is_a relation] is_a (inferred) gene silencing by RNA (GO:0031047)
RNA interference [Inferred is_a relation] is_a (inferred) posttranscriptional gene silencing (GO:0016441)
RNA interference [is_a relation] is_a  posttranscriptional gene silencing by RNA (GO:0035194)
Children of RNA interference (GO:0016246)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
conversion of ds siRNA to ss siRNA involved in RNA interference (GO:0033168) [part_of relation] part_of  RNA interference
mRNA cleavage involved in gene silencing by siRNA (GO:0090625) [part_of relation] part_of  RNA interference
mutator focus (GO:1990633) [capable_of part of relation] capable_of part of  RNA interference
negative regulation of RNA interference (GO:1900369) [negatively_regulates relation] negatively_regulates  RNA interference
negative regulation of translation involved in RNA interference (GO:0070549) [part_of relation] part_of  RNA interference
positive regulation of RNA interference (GO:1900370) [positively_regulates relation] positively_regulates  RNA interference
production of lsiRNA involved in RNA interference (GO:0010599) [part_of relation] part_of  RNA interference
production of siRNA involved in RNA interference (GO:0030422) [part_of relation] part_of  RNA interference
regulation of RNA interference (GO:1900368) [regulates relation] regulates  RNA interference
RNA interference involved in olfactory learning (GO:1903453) [is_a relation] is_a  RNA interference
siRNA loading onto RISC involved in RNA interference (GO:0035087) [part_of relation] part_of  RNA interference
targeting of mRNA for destruction involved in RNA interference (GO:0030423) [part_of relation] part_of  RNA interference
transitive RNA interference (GO:0036453) [is_a relation] is_a  RNA interference
Wikipedia
RNA_interference