Term Information [More information on macroautophagy]

alt. id: GO:0034262
autophagy in response to cellular starvation, non-specific autophagy, starvation-induced autophagy, autophagy
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. Source: PMID:12914914, PMID:16973210, PMID:9412464, PMID:15798367, PMID:20159618, PMID:11099404
Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities.
See term history for GO:0016236 at QuickGO
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Graph of GO:0016236 from QuickGO

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Ancestors of macroautophagy (GO:0016236)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
macroautophagy [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
macroautophagy [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
macroautophagy [is_a relation] is_a  autophagy (GO:0006914)
Children of macroautophagy (GO:0016236)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
aggrephagy (GO:0035973) [is_a relation] is_a  macroautophagy
autophagosome (GO:0005776) [capable_of part of relation] capable_of part of  macroautophagy
autophagosome maturation (GO:0097352) [part_of relation] part_of  macroautophagy
autophagosome organization (GO:1905037) [part_of relation] part_of  macroautophagy
engulfment of target by autophagosome (GO:0061736) [part_of relation] part_of  macroautophagy
glycophagy (GO:0061723) [is_a relation] is_a  macroautophagy
lipophagy (GO:0061724) [is_a relation] is_a  macroautophagy
macromitophagy (GO:0000423) [is_a relation] is_a  macroautophagy
macropexophagy (GO:0000425) [is_a relation] is_a  macroautophagy
negative regulation of macroautophagy (GO:0016242) [negatively_regulates relation] negatively_regulates  macroautophagy
negative regulation of macroautophagy by TORC1 signaling (GO:1904766) [negatively_regulates relation] negatively_regulates  macroautophagy
positive regulation of macroautophagy (GO:0016239) [positively_regulates relation] positively_regulates  macroautophagy
regulation of autophagosome size (GO:0016243) [part_of relation] part_of  macroautophagy
regulation of macroautophagy (GO:0016241) [regulates relation] regulates  macroautophagy
reticulophagy (GO:0061709) [is_a relation] is_a  macroautophagy
ribophagy (GO:0034517) [is_a relation] is_a  macroautophagy
xenophagy (GO:0098792) [is_a relation] is_a  macroautophagy