Term Information [More information on extrinsic apoptotic signaling pathway via death domain receptors]

Accession
GO:0008625
Name
extrinsic apoptotic signaling pathway via death domain receptors
Ontology
biological_process
Synonyms
induction of apoptosis via death receptors, induction of apoptosis via death domain receptors, death receptor-mediated apoptosis
Definition
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. Source: GOC:mtg_apoptosis, GOC:mah
Comment
Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
History
See term history for GO:0008625 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0008625 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway via death domain receptors [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) death (GO:0016265)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred part_of relation] part_of (inferred) apoptotic process (GO:0006915)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) apoptotic signaling pathway (GO:0097190)
extrinsic apoptotic signaling pathway via death domain receptors [Inferred is_a relation] is_a (inferred) cell surface receptor signaling pathway (GO:0007166)
extrinsic apoptotic signaling pathway via death domain receptors [is_a relation] is_a  extrinsic apoptotic signaling pathway (GO:0097191)
Children of extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042) [negatively_regulates relation] negatively_regulates  extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) [positively_regulates relation] positively_regulates  extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041) [regulates relation] regulates  extrinsic apoptotic signaling pathway via death domain receptors
TRAIL-activated apoptotic signaling pathway (GO:0036462) [is_a relation] is_a  extrinsic apoptotic signaling pathway via death domain receptors
None.