Term Information [More information on oxidized purine nucleobase lesion DNA N-glycosylase activity]

Accession
GO:0008534
Name
oxidized purine nucleobase lesion DNA N-glycosylase activity
Ontology
molecular_function
Synonyms
alt. id: GO:0003907
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity, DNA-formamidopyrimidine glycosylase activity, Fapy-DNA glycosylase activity, deoxyribonucleate glycosidase activity, formamidopyrimidine-DNA glycosylase activity, oxidized purine base lesion DNA N-glycosylase activity, DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing], Fpg protein, purine-specific oxidized base lesion DNA N-glycosylase activity, 8-oxoguanine DNA glycosylase activity, DNA glycosylase/AP-lyase activity, DNA glycosylase/beta-lyase activity, bifunctional DNA glycosylase activity
Definition
Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. Source: GOC:elh, PMID:11554296
Comment
Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
History
See term history for GO:0008534 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0008534 from QuickGO

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Ancestors of oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) cellular metabolic process (GO:0044237)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) nitrogen compound metabolic process (GO:0006807)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) organic substance metabolic process (GO:0071704)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) cellular aromatic compound metabolic process (GO:0006725)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) cellular nitrogen compound metabolic process (GO:0034641)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) heterocycle metabolic process (GO:0046483)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) organic cyclic compound metabolic process (GO:1901360)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) primary metabolic process (GO:0044238)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) macromolecule metabolic process (GO:0043170)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) nucleobase-containing compound metabolic process (GO:0006139)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) hydrolase activity (GO:0016787)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) nucleic acid metabolic process (GO:0090304)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) cellular macromolecule metabolic process (GO:0044260)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) hydrolase activity, acting on ester bonds (GO:0016788)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) nucleic acid phosphodiester bond hydrolysis (GO:0090305)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred part_of relation] part_of (inferred) DNA metabolic process (GO:0006259)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) hydrolase activity, acting on glycosyl bonds (GO:0016798)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) nuclease activity (GO:0004518)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) deoxyribonuclease activity (GO:0004536)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) endonuclease activity (GO:0004519)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) hydrolase activity, hydrolyzing N-glycosyl compounds (GO:0016799)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) lyase activity (GO:0016829)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) carbon-oxygen lyase activity (GO:0016835)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) DNA N-glycosylase activity (GO:0019104)
oxidized purine nucleobase lesion DNA N-glycosylase activity [Inferred is_a relation] is_a (inferred) endodeoxyribonuclease activity (GO:0004520)
oxidized purine nucleobase lesion DNA N-glycosylase activity [is_a relation] is_a  DNA-(apurinic or apyrimidinic site) lyase activity (GO:0003906)
oxidized purine nucleobase lesion DNA N-glycosylase activity [is_a relation] is_a  oxidized base lesion DNA N-glycosylase activity (GO:0000702)
Children of oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity (GO:0034039) [is_a relation] is_a  oxidized purine nucleobase lesion DNA N-glycosylase activity