Term Information [More information on IkappaB kinase complex]

Accession
GO:0008385
Name
IkappaB kinase complex
Ontology
cellular_component
Synonyms
IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Definition
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:20300203, PMID:12055104, GOC:bf, GOC:ma
Comment
None
History
See term history for GO:0008385 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0008385 from QuickGO

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Ancestors of IkappaB kinase complex (GO:0008385)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) metabolic process (GO:0008152)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular process (GO:0009987)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) organic substance metabolic process (GO:0071704)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) biological regulation (GO:0065007)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular metabolic process (GO:0044237)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) macromolecule metabolic process (GO:0043170)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) molecular_function (GO:0003674)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) primary metabolic process (GO:0044238)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism process (GO:0044699)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) catalytic activity (GO:0003824)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular macromolecule metabolic process (GO:0044260)
IkappaB kinase complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) macromolecule modification (GO:0043412)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) phosphorus metabolic process (GO:0006793)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) protein metabolic process (GO:0019538)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of biological process (GO:0050789)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) response to stimulus (GO:0050896)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) signaling (GO:0023052)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism cellular process (GO:0044763)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cell communication (GO:0007154)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular protein metabolic process (GO:0044267)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular response to stimulus (GO:0051716)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) phosphate-containing compound metabolic process (GO:0006796)
IkappaB kinase complex [is_a relation] is_a  protein complex (GO:0043234)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) protein modification process (GO:0036211)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular process (GO:0050794)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) single organism signaling (GO:0044700)
IkappaB kinase complex [Inferred capable_of relation] capable_of (inferred) transferase activity (GO:0016740)
IkappaB kinase complex [Inferred is_a relation] is_a (inferred) catalytic complex (GO:1902494)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular protein modification process (GO:0006464)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) phosphorylation (GO:0016310)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) signal transduction (GO:0007165)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) transferase activity, transferring phosphorus-containing groups (GO:0016772)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) intracellular signal transduction (GO:0035556)
IkappaB kinase complex [Inferred capable_of relation] capable_of (inferred) kinase activity (GO:0016301)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) phosphotransferase activity, alcohol group as acceptor (GO:0016773)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) protein phosphorylation (GO:0006468)
IkappaB kinase complex [Inferred is_a relation] is_a (inferred) transferase complex (GO:1990234)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cytoplasmic part (GO:0044444)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) I-kappaB kinase/NF-kappaB signaling (GO:0007249)
IkappaB kinase complex [Inferred capable_of relation] capable_of (inferred) protein kinase activity (GO:0004672)
IkappaB kinase complex [Inferred is_a relation] is_a (inferred) transferase complex, transferring phosphorus-containing groups (GO:0061695)
IkappaB kinase complex [Inferred part_of relation] part_of (inferred) cytosol (GO:0005829)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) I-kappaB phosphorylation (GO:0007252)
IkappaB kinase complex [Inferred is_a relation] is_a (inferred) protein kinase complex (GO:1902911)
IkappaB kinase complex [Inferred capable_of relation] capable_of (inferred) protein serine/threonine kinase activity (GO:0004674)
IkappaB kinase complex [is_a relation] is_a  cytosolic part (GO:0044445)
IkappaB kinase complex [Inferred capable_of part of relation] capable_of part of (inferred) IkappaB kinase activity (GO:0008384)
IkappaB kinase complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)

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