Term Information [More information on cell death]

Accession
GO:0008219
Name
cell death
Ontology
biological_process
Synonyms
accidental cell death, necrosis
Definition
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). Source: PMID:25236395, GOC:mtg_apoptosis, GOC:mah
Comment
This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
History
See term history for GO:0008219 at QuickGO
Subset
gosubset_prok
goslim_plant
goslim_generic
goslim_chembl
Community
GN View or edit usage comments for this term on the GONUTS wiki.
Feedback
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Graph of GO:0008219 from QuickGO

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Ancestors of cell death (GO:0008219)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cell death [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
cell death [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
cell death [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
cell death [is_a relation] is_a  single-organism cellular process (GO:0044763)
Children of cell death (GO:0008219)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cell death in response to oxidative stress (GO:0036473) [is_a relation] is_a  cell death
necrotic cell death (GO:0070265) [is_a relation] is_a  cell death
negative regulation of cell death (GO:0060548) [negatively_regulates relation] negatively_regulates  cell death
neuron death (GO:0070997) [is_a relation] is_a  cell death
positive regulation of cell death (GO:0010942) [positively_regulates relation] positively_regulates  cell death
programmed cell death (GO:0012501) [is_a relation] is_a  cell death
regulation of cell death (GO:0010941) [regulates relation] regulates  cell death
salivary gland cell autophagic cell death (GO:0035071) [is_a relation] is_a  cell death
None.