Term Information [More information on JAK-STAT cascade]

Accession
GO:0007259
Name
JAK-STAT cascade
Ontology
biological_process
Synonyms
JAK-STAT signal transduction
Definition
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. Source: PMID:12039028, GOC:signaling, GOC:jl, GOC:bf
Comment
None
History
See term history for GO:0007259 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0007259 from QuickGO

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Ancestors of JAK-STAT cascade (GO:0007259)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
JAK-STAT cascade [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
JAK-STAT cascade [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
JAK-STAT cascade [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
JAK-STAT cascade [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
JAK-STAT cascade [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
JAK-STAT cascade [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
JAK-STAT cascade [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
JAK-STAT cascade [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
JAK-STAT cascade [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
JAK-STAT cascade [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
JAK-STAT cascade [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
JAK-STAT cascade [Inferred is_a relation] is_a (inferred) intracellular signal transduction (GO:0035556)
JAK-STAT cascade [is_a relation] is_a  STAT cascade (GO:0097696)
Children of JAK-STAT cascade (GO:0007259)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) [is_a relation] is_a  JAK-STAT cascade
negative regulation of JAK-STAT cascade (GO:0046426) [negatively_regulates relation] negatively_regulates  JAK-STAT cascade
positive regulation of JAK-STAT cascade (GO:0046427) [positively_regulates relation] positively_regulates  JAK-STAT cascade
regulation of JAK-STAT cascade (GO:0046425) [regulates relation] regulates  JAK-STAT cascade
STAT protein import into nucleus (GO:0007262) [part_of relation] part_of  JAK-STAT cascade
tyrosine phosphorylation of STAT protein (GO:0007260) [part_of relation] part_of  JAK-STAT cascade