Term Information [More information on JNK cascade]

Accession
GO:0007254
Name
JNK cascade
Ontology
biological_process
Synonyms
c-Jun N-terminal kinase cascade, JNK1 cascade, JNK2 cascade, JNK3 cascade, MAPK10 cascade, MAPK8 cascade, MAPK9 cascade, SAPK cascade, stress-activated protein kinase cascade
Definition
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. Source: PMID:11790549, PMID:20811974, GOC:signaling, GOC:bf
Comment
None
History
See term history for GO:0007254 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0007254 from QuickGO

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Ancestors of JNK cascade (GO:0007254)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
JNK cascade [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
JNK cascade [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
JNK cascade [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
JNK cascade [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
JNK cascade [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
JNK cascade [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
JNK cascade [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
JNK cascade [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
JNK cascade [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
JNK cascade [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
JNK cascade [Inferred is_a relation] is_a (inferred) macromolecule modification (GO:0043412)
JNK cascade [Inferred is_a relation] is_a (inferred) phosphorus metabolic process (GO:0006793)
JNK cascade [Inferred is_a relation] is_a (inferred) protein metabolic process (GO:0019538)
JNK cascade [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
JNK cascade [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
JNK cascade [Inferred is_a relation] is_a (inferred) cellular protein metabolic process (GO:0044267)
JNK cascade [Inferred is_a relation] is_a (inferred) phosphate-containing compound metabolic process (GO:0006796)
JNK cascade [Inferred is_a relation] is_a (inferred) protein modification process (GO:0036211)
JNK cascade [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
JNK cascade [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
JNK cascade [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
JNK cascade [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
JNK cascade [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
JNK cascade [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
JNK cascade [Inferred is_a relation] is_a (inferred) cellular protein modification process (GO:0006464)
JNK cascade [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
JNK cascade [Inferred is_a relation] is_a (inferred) phosphorylation (GO:0016310)
JNK cascade [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
JNK cascade [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
JNK cascade [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
JNK cascade [Inferred is_a relation] is_a (inferred) protein phosphorylation (GO:0006468)
JNK cascade [Inferred is_a relation] is_a (inferred) response to stress (GO:0006950)
JNK cascade [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
JNK cascade [Inferred is_a relation] is_a (inferred) single-organism metabolic process (GO:0044710)
JNK cascade [Inferred is_a relation] is_a (inferred) cellular response to stress (GO:0033554)
JNK cascade [Inferred is_a relation] is_a (inferred) intracellular signal transduction (GO:0035556)
JNK cascade [Inferred is_a relation] is_a (inferred) signal transduction by protein phosphorylation (GO:0023014)
JNK cascade [Inferred is_a relation] is_a (inferred) MAPK cascade (GO:0000165)
JNK cascade [Inferred is_a relation] is_a (inferred) stress-activated protein kinase signaling cascade (GO:0031098)
JNK cascade [is_a relation] is_a  stress-activated MAPK cascade (GO:0051403)
Children of JNK cascade (GO:0007254)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of JNKK activity (GO:0007256) [part_of relation] part_of  JNK cascade
activation of JNKKK activity (GO:0042655) [part_of relation] part_of  JNK cascade
activation of JUN kinase activity (GO:0007257) [part_of relation] part_of  JNK cascade
JUN phosphorylation (GO:0007258) [part_of relation] part_of  JNK cascade
negative regulation of JNK cascade (GO:0046329) [negatively_regulates relation] negatively_regulates  JNK cascade
positive regulation of JNK cascade (GO:0046330) [positively_regulates relation] positively_regulates  JNK cascade
regulation of JNK cascade (GO:0046328) [regulates relation] regulates  JNK cascade