Term Information [More information on I-kappaB phosphorylation]

Accession
GO:0007252
Name
I-kappaB phosphorylation
Ontology
biological_process
Synonyms
IKB phosphorylation, IkappaB phosphorylation, inhibitor of NF-kappaB phosphorylation, inhibitor of kappaB phosphorylation
Definition
The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:7594468, GOC:jl, GOC:bf, PMID:21772278
Comment
None
History
See term history for GO:0007252 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
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Graph of GO:0007252 from QuickGO

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Ancestors of I-kappaB phosphorylation (GO:0007252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) biological regulation (GO:0065007)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
I-kappaB phosphorylation [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
I-kappaB phosphorylation [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) regulation of biological process (GO:0050789)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
I-kappaB phosphorylation [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) macromolecule modification (GO:0043412)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) phosphorus metabolic process (GO:0006793)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) protein metabolic process (GO:0019538)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) regulation of cellular process (GO:0050794)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) cellular protein metabolic process (GO:0044267)
I-kappaB phosphorylation [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) phosphate-containing compound metabolic process (GO:0006796)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) protein modification process (GO:0036211)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) signal transduction (GO:0007165)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) cellular protein modification process (GO:0006464)
I-kappaB phosphorylation [Inferred part_of relation] part_of (inferred) intracellular signal transduction (GO:0035556)
I-kappaB phosphorylation [Inferred is_a relation] is_a (inferred) phosphorylation (GO:0016310)
I-kappaB phosphorylation [part_of relation] part_of  I-kappaB kinase/NF-kappaB signaling (GO:0007249)
I-kappaB phosphorylation [is_a relation] is_a  protein phosphorylation (GO:0006468)
Children of I-kappaB phosphorylation (GO:0007252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase activity (GO:0008384) [part_of relation] part_of  I-kappaB phosphorylation
negative regulation of I-kappaB phosphorylation (GO:1903720) [negatively_regulates relation] negatively_regulates  I-kappaB phosphorylation
positive regulation of I-kappaB phosphorylation (GO:1903721) [positively_regulates relation] positively_regulates  I-kappaB phosphorylation
regulation of I-kappaB phosphorylation (GO:1903719) [regulates relation] regulates  I-kappaB phosphorylation
None.