Term Information [More information on I-kappaB kinase/NF-kappaB signaling]

Accession
GO:0007249
Name
I-kappaB kinase/NF-kappaB signaling
Ontology
biological_process
Synonyms
I-kappaB kinase/NF-kappaB signal transduction, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, activation of the inhibitor of kappa kinase, p50-dependent NF-kappaB signaling, NF-kappaB cascade
Definition
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:jl, Reactome:REACT_13696.1, GOC:bf, PMID:12773372
Comment
None
History
See term history for GO:0007249 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0007249 from QuickGO

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Ancestors of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB kinase/NF-kappaB signaling [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
I-kappaB kinase/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
I-kappaB kinase/NF-kappaB signaling [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
I-kappaB kinase/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
I-kappaB kinase/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
I-kappaB kinase/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
I-kappaB kinase/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
I-kappaB kinase/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
I-kappaB kinase/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
I-kappaB kinase/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
I-kappaB kinase/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
I-kappaB kinase/NF-kappaB signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB phosphorylation (GO:0007252) [part_of relation] part_of  I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124) [negatively_regulates relation] negatively_regulates  I-kappaB kinase/NF-kappaB signaling
NF-kappaB import into nucleus (GO:0042348) [part_of relation] part_of  I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) [positively_regulates relation] positively_regulates  I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) [regulates relation] regulates  I-kappaB kinase/NF-kappaB signaling
release of cytoplasmic sequestered NF-kappaB (GO:0008588) [part_of relation] part_of  I-kappaB kinase/NF-kappaB signaling