Term Information [More information on G-protein coupled receptor signaling pathway]

Accession
GO:0007186
Name
G-protein coupled receptor signaling pathway
Ontology
biological_process
Synonyms
G protein coupled receptor protein signaling pathway, G protein coupled receptor protein signalling pathway, G-protein coupled receptor protein signal transduction, G-protein coupled receptor protein signaling pathway, G-protein coupled receptor signalling pathway, G-protein-coupled receptor protein signaling pathway, G-protein-coupled receptor protein signalling pathway, GPCR signaling pathway, GPCR signalling pathway
Definition
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576). Source: PMID:16902576PMID:24568158, GOC:mah, GOC:bf, Wikipedia:G_protein-coupled_receptor
Comment
None
History
See term history for GO:0007186 at QuickGO
Subset
None
Community
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Graph of GO:0007186 from QuickGO

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Ancestors of G-protein coupled receptor signaling pathway (GO:0007186)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
G-protein coupled receptor signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
G-protein coupled receptor signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
G-protein coupled receptor signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
G-protein coupled receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
G-protein coupled receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
G-protein coupled receptor signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
G-protein coupled receptor signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
Children of G-protein coupled receptor signaling pathway (GO:0007186)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
adrenergic receptor signaling pathway (GO:0071875) [is_a relation] is_a  G-protein coupled receptor signaling pathway
angiotensin-activated signaling pathway (GO:0038166) [is_a relation] is_a  G-protein coupled receptor signaling pathway
apelin receptor signaling pathway (GO:0060183) [is_a relation] is_a  G-protein coupled receptor signaling pathway
bombesin receptor signaling pathway (GO:0031989) [is_a relation] is_a  G-protein coupled receptor signaling pathway
calcitonin family receptor signaling pathway (GO:0097646) [is_a relation] is_a  G-protein coupled receptor signaling pathway
cannabinoid signaling pathway (GO:0038171) [is_a relation] is_a  G-protein coupled receptor signaling pathway
cholecystokinin signaling pathway (GO:0038188) [is_a relation] is_a  G-protein coupled receptor signaling pathway
complement component C5a signaling pathway (GO:0038178) [is_a relation] is_a  G-protein coupled receptor signaling pathway
dimeric G-protein coupled receptor signaling pathway (GO:0038042) [is_a relation] is_a  G-protein coupled receptor signaling pathway
dopamine receptor signaling pathway (GO:0007212) [is_a relation] is_a  G-protein coupled receptor signaling pathway
endothelin receptor signaling pathway (GO:0086100) [is_a relation] is_a  G-protein coupled receptor signaling pathway
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway (GO:0035625) [is_a relation] is_a  G-protein coupled receptor signaling pathway
follicle-stimulating hormone signaling pathway (GO:0042699) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway (GO:0007216) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled neurotransmitter receptor activity (GO:0099528) [part_of relation] part_of  G-protein coupled receptor signaling pathway
G-protein coupled purinergic receptor signaling pathway (GO:0035588) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor activity (GO:0004930) [part_of relation] part_of  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling in absence of ligand (GO:0038035) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway involved in dauer larval development (GO:1904066) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacterium (GO:1903554) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway involved in heart process (GO:0086103) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway involved in social behavior (GO:1904068) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) [is_a relation] is_a  G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to S1P second messenger (GO:0001789) [is_a relation] is_a  G-protein coupled receptor signaling pathway
gamma-aminobutyric acid signaling pathway (GO:0007214) [is_a relation] is_a  G-protein coupled receptor signaling pathway
gastric inhibitory peptide signaling pathway (GO:0038192) [is_a relation] is_a  G-protein coupled receptor signaling pathway
heterotrimeric G-protein complex cycle (GO:0031684) [part_of relation] part_of  G-protein coupled receptor signaling pathway
leukotriene signaling pathway (GO:0061737) [is_a relation] is_a  G-protein coupled receptor signaling pathway
luteinizing hormone signaling pathway (GO:0042700) [is_a relation] is_a  G-protein coupled receptor signaling pathway
negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744) [negatively_regulates relation] negatively_regulates  G-protein coupled receptor signaling pathway
neuropeptide signaling pathway (GO:0007218) [is_a relation] is_a  G-protein coupled receptor signaling pathway
octopamine or tyramine signaling pathway (GO:0007211) [is_a relation] is_a  G-protein coupled receptor signaling pathway
opioid receptor signaling pathway (GO:0038003) [is_a relation] is_a  G-protein coupled receptor signaling pathway
pheromone-dependent signal transduction involved in conjugation with cellular fusion (GO:0000750) [is_a relation] is_a  G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) [is_a relation] is_a  G-protein coupled receptor signaling pathway
phospholipase C-inhibiting G-protein coupled receptor signaling pathway (GO:0030845) [is_a relation] is_a  G-protein coupled receptor signaling pathway
phospholipase D-activating G-protein coupled receptor signaling pathway (GO:0031583) [is_a relation] is_a  G-protein coupled receptor signaling pathway
positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745) [positively_regulates relation] positively_regulates  G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205) [is_a relation] is_a  G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277) [regulates relation] regulates  G-protein coupled receptor signaling pathway
rhodopsin mediated signaling pathway (GO:0016056) [is_a relation] is_a  G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway (GO:0007210) [is_a relation] is_a  G-protein coupled receptor signaling pathway
signal transduction involved in conjugation with mutual genetic exchange (GO:0000757) [is_a relation] is_a  G-protein coupled receptor signaling pathway
somatostatin receptor signaling pathway (GO:0038169) [is_a relation] is_a  G-protein coupled receptor signaling pathway
sphingosine-1-phosphate signaling pathway (GO:0003376) [is_a relation] is_a  G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway (GO:0007217) [is_a relation] is_a  G-protein coupled receptor signaling pathway
thrombin receptor signaling pathway (GO:0070493) [is_a relation] is_a  G-protein coupled receptor signaling pathway
thromboxane A2 signaling pathway (GO:0038193) [is_a relation] is_a  G-protein coupled receptor signaling pathway
thyroid-stimulating hormone signaling pathway (GO:0038194) [is_a relation] is_a  G-protein coupled receptor signaling pathway
None.