Term Information [More information on signal transduction]

Accession
GO:0007165
Name
signal transduction
Ontology
biological_process
Synonyms
alt. id: GO:0023033
signaling pathway, signalling pathway, signaling cascade, signalling cascade
Definition
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Source: GOC:go_curators, GOC:mtg_signaling_feb11
Comment
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
History
See term history for GO:0007165 at QuickGO
Subset
gosubset_prok
goslim_plant
goslim_generic
goslim_candida
goslim_aspergillus
goslim_chembl
goslim_metagenomics
Community
GN View or edit usage comments for this term on the GONUTS wiki.
Feedback
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Graph of GO:0007165 from QuickGO

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Ancestors of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
signal transduction [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
signal transduction [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
signal transduction [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
signal transduction [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
signal transduction [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
signal transduction [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
signal transduction [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
signal transduction [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
signal transduction [part_of relation] part_of  cell communication (GO:0007154)
signal transduction [part_of relation] part_of  cellular response to stimulus (GO:0051716)
signal transduction [is_a relation] is_a  regulation of cellular process (GO:0050794)
signal transduction [part_of relation] part_of  single organism signaling (GO:0044700)
Children of signal transduction (GO:0007165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
acetylcholine receptor signaling pathway (GO:0095500) [is_a relation] is_a  signal transduction
adrenergic receptor signaling pathway (GO:0071875) [is_a relation] is_a  signal transduction
apoptotic signaling pathway (GO:0097190) [is_a relation] is_a  signal transduction
bile acid signaling pathway (GO:0038183) [is_a relation] is_a  signal transduction
cannabinoid signaling pathway (GO:0038171) [is_a relation] is_a  signal transduction
carbohydrate mediated signaling (GO:0009756) [is_a relation] is_a  signal transduction
cell surface receptor signaling pathway (GO:0007166) [is_a relation] is_a  signal transduction
chloroplast-nucleus signaling pathway (GO:0010019) [is_a relation] is_a  signal transduction
defense response signaling pathway, resistance gene-dependent (GO:0009870) [is_a relation] is_a  signal transduction
defense response signaling pathway, resistance gene-independent (GO:0010204) [is_a relation] is_a  signal transduction
endoplasmic reticulum unfolded protein response (GO:0030968) [is_a relation] is_a  signal transduction
endosomal signal transduction (GO:2000803) [is_a relation] is_a  signal transduction
ER-nucleus signaling pathway (GO:0006984) [is_a relation] is_a  signal transduction
G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) [is_a relation] is_a  signal transduction
G-protein coupled receptor signaling pathway (GO:0007186) [is_a relation] is_a  signal transduction
hormone-mediated signaling pathway (GO:0009755) [is_a relation] is_a  signal transduction
hydrogen peroxide mediated signaling pathway (GO:0071588) [is_a relation] is_a  signal transduction
hypoxia-inducible factor-1alpha signaling pathway (GO:0097411) [is_a relation] is_a  signal transduction
immune response-regulating signaling pathway (GO:0002764) [is_a relation] is_a  signal transduction
intracellular receptor signaling pathway (GO:0030522) [is_a relation] is_a  signal transduction
intracellular signal transduction (GO:0035556) [is_a relation] is_a  signal transduction
lipoprotein particle mediated signaling (GO:0055095) [is_a relation] is_a  signal transduction
mitochondria-nucleus signaling pathway (GO:0031930) [is_a relation] is_a  signal transduction
necroptotic signaling pathway (GO:0097527) [is_a relation] is_a  signal transduction
negative regulation of signal transduction (GO:0009968) [negatively_regulates relation] negatively_regulates  signal transduction
negative regulation of signal transduction by receptor internalization (GO:0038011) [negatively_regulates relation] negatively_regulates  signal transduction
neuronal signal transduction (GO:0023041) [is_a relation] is_a  signal transduction
osmosensory signaling pathway (GO:0007231) [is_a relation] is_a  signal transduction
phototransduction (GO:0007602) [is_a relation] is_a  signal transduction
positive regulation of signal transduction (GO:0009967) [positively_regulates relation] positively_regulates  signal transduction
positive regulation of signal transduction by receptor internalization (GO:0038010) [positively_regulates relation] positively_regulates  signal transduction
postsynapse to nucleus signaling pathway (GO:0099527) [is_a relation] is_a  signal transduction
postsynaptic signal transduction (GO:0098926) [is_a relation] is_a  signal transduction
presynapse to nucleus signaling pathway (GO:0099526) [is_a relation] is_a  signal transduction
presynaptic signal transduction (GO:0098928) [is_a relation] is_a  signal transduction
receptor agonist activity (GO:0048018) [part_of relation] part_of  signal transduction
red or far-red light signaling pathway (GO:0010017) [is_a relation] is_a  signal transduction
regulation of blood pressure by chemoreceptor signaling pathway (GO:0010850) [is_a relation] is_a  signal transduction
regulation of floral organ abscission by signal transduction (GO:0060863) [is_a relation] is_a  signal transduction
regulation of signal transduction (GO:0009966) [regulates relation] regulates  signal transduction
regulation of signal transduction by receptor internalization (GO:0038009) [regulates relation] regulates  signal transduction
salicylic acid mediated signaling pathway (GO:0009863) [is_a relation] is_a  signal transduction
second-messenger-mediated signaling (GO:0019932) [is_a relation] is_a  signal transduction
signal transducer activity (GO:0004871) [part_of relation] part_of  signal transduction
signal transduction by conformational transition (GO:0023045) [is_a relation] is_a  signal transduction
signal transduction by protein phosphorylation (GO:0023014) [is_a relation] is_a  signal transduction
signal transduction in absence of ligand (GO:0038034) [is_a relation] is_a  signal transduction
signal transduction involved in cellular response to ammonium ion (GO:1903831) [is_a relation] is_a  signal transduction
signal transduction involved in conjugation with cellular fusion (GO:0032005) [is_a relation] is_a  signal transduction
signal transduction involved in conjugation with mutual genetic exchange (GO:0000757) [is_a relation] is_a  signal transduction
signal transduction involved in Dma1-dependent checkpoint (GO:1902420) [is_a relation] is_a  signal transduction
signal transduction involved in filamentous growth (GO:0001402) [is_a relation] is_a  signal transduction
signal transduction involved in mitotic cytokinesis checkpoint (GO:1903820) [is_a relation] is_a  signal transduction
signal transduction involved in mitotic G2 DNA damage checkpoint (GO:0072434) [is_a relation] is_a  signal transduction
signal transduction involved in morphogenesis checkpoint (GO:1903822) [is_a relation] is_a  signal transduction
signal transduction involved in regulation of aerobic respiration (GO:1903759) [is_a relation] is_a  signal transduction
signal transduction involved in regulation of gene expression (GO:0023019) [is_a relation] is_a  signal transduction
signaling receptor activity (GO:0038023) [part_of relation] part_of  signal transduction
SMAD protein signal transduction (GO:0060395) [is_a relation] is_a  signal transduction
small GTPase mediated signal transduction (GO:0007264) [is_a relation] is_a  signal transduction
sphingolipid mediated signaling pathway (GO:0090520) [is_a relation] is_a  signal transduction
transmembrane signaling receptor activity (GO:0004888) [part_of relation] part_of  signal transduction