AmiGO 2: Term Details for "activation of cysteine-type endopeptidase activity involved in apoptotic process" (GO:0006919)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0006919
Name: activation of cysteine-type endopeptidase activity involved in apoptotic process
Ontology: biological_process
Synonyms: caspase activation, activation of caspase activity, activation of metacaspase activity
Alternate IDs: None
Definition: Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. Source: PMID:14744432, Wikipedia:Caspase, PMID:18328827, GOC:dph, GOC:jl, GOC:tb, GOC:mtg_apoptosis, GOC:al
Comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
History: See term history for GO:0006919 at QuickGO
Subset: None
Related: Link to all genes and gene products annotated to activation of cysteine-type endopeptidase activity involved in apoptotic process.; Link to all direct and indirect annotations to activation of cysteine-type endopeptidase activity involved in apoptotic process.; Link to all direct and indirect annotations download (limited to first 10,000) for activation of cysteine-type endopeptidase activity involved in apoptotic process.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0008150 biological_process
GO:0065007 biological regulation
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0050789 regulation of biological process
GO:0044237 cellular metabolic process
GO:0043170 macromolecule metabolic process
GO:0003674 molecular_function
GO:1901564 organonitrogen compound metabolic process
GO:0048518 positive regulation of biological process
GO:0044238 primary metabolic process
GO:0019222 regulation of metabolic process
GO:0003824 catalytic activity
GO:0044260 cellular macromolecule metabolic process
GO:0009893 positive regulation of metabolic process
GO:0019538 protein metabolic process
GO:0050794 regulation of cellular process
GO:0060255 regulation of macromolecule metabolic process
GO:0051171 regulation of nitrogen compound metabolic process
GO:0080090 regulation of primary metabolic process
GO:0044267 cellular protein metabolic process
GO:0016787 hydrolase activity
GO:0048522 positive regulation of cellular process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0006508 proteolysis
GO:0031323 regulation of cellular metabolic process
GO:0065009 regulation of molecular function
GO:0051246 regulation of protein metabolic process
GO:0044699 single-organism process
GO:0008233 peptidase activity
GO:0031325 positive regulation of cellular metabolic process
GO:0044093 positive regulation of molecular function
GO:0051247 positive regulation of protein metabolic process
GO:0050790 regulation of catalytic activity
GO:0032268 regulation of cellular protein metabolic process
GO:0044763 single-organism cellular process
GO:0008219 cell death
GO:0070011 peptidase activity, acting on L-amino acid peptides
GO:0043085 positive regulation of catalytic activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0051336 regulation of hydrolase activity
GO:0030162 regulation of proteolysis
GO:0008234 cysteine-type peptidase activity
GO:0004175 endopeptidase activity
GO:0051345 positive regulation of hydrolase activity
GO:0045862 positive regulation of proteolysis
GO:0012501 programmed cell death
GO:0010941 regulation of cell death
GO:0052547 regulation of peptidase activity
GO:0006915 apoptotic process
GO:0004197 cysteine-type endopeptidase activity
GO:0010942 positive regulation of cell death
GO:0010952 positive regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0043067 regulation of programmed cell death
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0010950 positive regulation of endopeptidase activity
GO:0043068 positive regulation of programmed cell death
GO:0042981 regulation of apoptotic process
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:0043065 positive regulation of apoptotic process
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process

Parents of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)

subject	relation	object
activation of cysteine-type endopeptidase activity involved in apoptotic process	is_a	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)

Children of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)

subject	relation	object
cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656)	part_of	activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO:0008635)	is_a	activation of cysteine-type endopeptidase activity involved in apoptotic process

Reactome: REACT_96857; REACT_99084; REACT_108966; REACT_110733; REACT_109094; REACT_103096; REACT_832; REACT_93871; REACT_96984