Term Information [More information on activation of cysteine-type endopeptidase activity involved in apoptotic process]

Accession
GO:0006919
Name
activation of cysteine-type endopeptidase activity involved in apoptotic process
Ontology
biological_process
Synonyms
caspase activation, activation of caspase activity, activation of metacaspase activity
Definition
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. Source: GOC:dph, PMID:14744432, Wikipedia:Caspase, PMID:18328827, GOC:al, GOC:tb, GOC:mtg_apoptosis, GOC:jl
Comment
This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
History
See term history for GO:0006919 at QuickGO
Subset
None
Community
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Graph of GO:0006919 from QuickGO

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Ancestors of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) biological_process (GO:0008150)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) metabolic process (GO:0008152)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cellular process (GO:0009987)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) organic substance metabolic process (GO:0071704)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cellular metabolic process (GO:0044237)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) macromolecule metabolic process (GO:0043170)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) molecular_function (GO:0003674)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of biological process (GO:0048518)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) primary metabolic process (GO:0044238)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of metabolic process (GO:0019222)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) catalytic activity (GO:0003824)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cellular macromolecule metabolic process (GO:0044260)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of metabolic process (GO:0009893)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) protein metabolic process (GO:0019538)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of macromolecule metabolic process (GO:0060255)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of primary metabolic process (GO:0080090)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cellular protein metabolic process (GO:0044267)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) hydrolase activity (GO:0016787)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of cellular process (GO:0048522)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of macromolecule metabolic process (GO:0010604)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) proteolysis (GO:0006508)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cellular metabolic process (GO:0031323)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of molecular function (GO:0065009)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of protein metabolic process (GO:0051246)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) single-organism process (GO:0044699)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) peptidase activity (GO:0008233)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of cellular metabolic process (GO:0031325)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of molecular function (GO:0044093)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of protein metabolic process (GO:0051247)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of catalytic activity (GO:0050790)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cellular protein metabolic process (GO:0032268)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) single-organism cellular process (GO:0044763)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cell death (GO:0008219)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) peptidase activity, acting on L-amino acid peptides (GO:0070011)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of catalytic activity (GO:0043085)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of cellular protein metabolic process (GO:0032270)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of hydrolase activity (GO:0051336)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of proteolysis (GO:0030162)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cysteine-type peptidase activity (GO:0008234)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) endopeptidase activity (GO:0004175)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred part_of relation] part_of (inferred) gene expression (GO:0010467)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of hydrolase activity (GO:0051345)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of proteolysis (GO:0045862)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) programmed cell death (GO:0012501)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cell death (GO:0010941)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of peptidase activity (GO:0052547)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) apoptotic process (GO:0006915)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cysteine-type endopeptidase activity (GO:0004197)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of cell death (GO:0010942)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of peptidase activity (GO:0010952)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) protein maturation (GO:0051604)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of endopeptidase activity (GO:0052548)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of programmed cell death (GO:0043067)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred positively_regulates relation] positively_regulates (inferred) cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of endopeptidase activity (GO:0010950)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of programmed cell death (GO:0043068)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) protein processing (GO:0016485)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of apoptotic process (GO:0042981)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cysteine-type endopeptidase activity (GO:2000116)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of apoptotic process (GO:0043065)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) positive regulation of cysteine-type endopeptidase activity (GO:2001056)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)
activation of cysteine-type endopeptidase activity involved in apoptotic process [Inferred is_a relation] is_a (inferred) zymogen activation (GO:0031638)
activation of cysteine-type endopeptidase activity involved in apoptotic process [is_a relation] is_a  activation of cysteine-type endopeptidase activity (GO:0097202)
activation of cysteine-type endopeptidase activity involved in apoptotic process [is_a relation] is_a  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)
Children of activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO:0008635) [is_a relation] is_a  activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097296) [is_a relation] is_a  activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis (GO:0097297) [is_a relation] is_a  activation of cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activator activity involved in apoptotic process (GO:0008656) [part_of relation] part_of  activation of cysteine-type endopeptidase activity involved in apoptotic process