Term Information [More information on apoptotic process]

Accession
GO:0006915
Name
apoptotic process
Ontology
biological_process
Synonyms
alt. id: GO:0008632, GO:0006917
apoptotic cell death, apoptotic programmed cell death, programmed cell death by apoptosis, apoptosis activator activity, caspase-dependent programmed cell death, commitment to apoptosis, induction of apoptosis, induction of apoptosis by p53, signaling (initiator) caspase activity, activation of apoptosis, apoptosis, apoptosis signaling, apoptotic program, type I programmed cell death, cell suicide, cellular suicide
Definition
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. Source: GOC:go_curators, PMID:21494263, GOC:dhl, GOC:tb, GOC:cjm, GOC:ecd, GOC:mtg_apoptosis, ISBN:0198506732, PMID:18846107
Comment
None
History
See term history for GO:0006915 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0006915 from QuickGO

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Ancestors of apoptotic process (GO:0006915)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic process [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
apoptotic process [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
apoptotic process [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
apoptotic process [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
apoptotic process [Inferred is_a relation] is_a (inferred) cell death (GO:0008219)
apoptotic process [is_a relation] is_a  programmed cell death (GO:0012501)
Children of apoptotic process (GO:0006915)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) [part_of relation] part_of  apoptotic process
anoikis (GO:0043276) [is_a relation] is_a  apoptotic process
apoptotic mitochondrial changes (GO:0008637) [part_of relation] part_of  apoptotic process
apoptotic process in bone marrow (GO:0071839) [is_a relation] is_a  apoptotic process
apoptotic process involved in atrial ventricular junction remodeling (GO:0003296) [is_a relation] is_a  apoptotic process
apoptotic process involved in development (GO:1902742) [is_a relation] is_a  apoptotic process
apoptotic process involved in embryonic digit morphogenesis (GO:1902263) [is_a relation] is_a  apoptotic process
apoptotic process involved in endocardial cushion morphogenesis (GO:0003277) [is_a relation] is_a  apoptotic process
apoptotic process involved in heart morphogenesis (GO:0003278) [is_a relation] is_a  apoptotic process
apoptotic process involved in heart valve morphogenesis (GO:0003276) [is_a relation] is_a  apoptotic process
apoptotic process involved in luteolysis (GO:0061364) [is_a relation] is_a  apoptotic process
apoptotic process involved in mammary gland involution (GO:0060057) [is_a relation] is_a  apoptotic process
apoptotic process involved in metanephric collecting duct development (GO:1900204) [is_a relation] is_a  apoptotic process
apoptotic process involved in metanephric nephron tubule development (GO:1900205) [is_a relation] is_a  apoptotic process
apoptotic process involved in morphogenesis (GO:0060561) [is_a relation] is_a  apoptotic process
apoptotic process involved in outflow tract morphogenesis (GO:0003275) [is_a relation] is_a  apoptotic process
apoptotic process involved in patterning of blood vessels (GO:1902262) [is_a relation] is_a  apoptotic process
apoptotic process involved in salivary gland cavitation (GO:0060663) [is_a relation] is_a  apoptotic process
apoptotic process involved in tube lumen cavitation (GO:0060609) [is_a relation] is_a  apoptotic process
apoptotic signaling pathway (GO:0097190) [part_of relation] part_of  apoptotic process
B cell apoptotic process (GO:0001783) [is_a relation] is_a  apoptotic process
cardiac muscle cell apoptotic process (GO:0010659) [is_a relation] is_a  apoptotic process
cholangiocyte apoptotic process (GO:1902488) [is_a relation] is_a  apoptotic process
compound eye retinal cell apoptotic process (GO:1990010) [is_a relation] is_a  apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153) [part_of relation] part_of  apoptotic process
cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027) [part_of relation] part_of  apoptotic process
cytotoxic T cell apoptotic process (GO:1902483) [is_a relation] is_a  apoptotic process
dendritic cell apoptotic process (GO:0097048) [is_a relation] is_a  apoptotic process
endothelial cell apoptotic process (GO:0072577) [is_a relation] is_a  apoptotic process
epithelial cell apoptotic process (GO:1904019) [is_a relation] is_a  apoptotic process
erythrocyte apoptotic process (GO:1902217) [is_a relation] is_a  apoptotic process
execution phase of apoptosis (GO:0097194) [part_of relation] part_of  apoptotic process
fat cell apoptotic process (GO:1904606) [is_a relation] is_a  apoptotic process
fibroblast apoptotic process (GO:0044346) [is_a relation] is_a  apoptotic process
glial cell apoptotic process (GO:0034349) [is_a relation] is_a  apoptotic process
glomerular visceral epithelial cell apoptotic process (GO:1903210) [is_a relation] is_a  apoptotic process
granulosa cell apoptotic process (GO:1904700) [is_a relation] is_a  apoptotic process
hepatoblast apoptotic process (GO:1902489) [is_a relation] is_a  apoptotic process
hepatocyte apoptotic process (GO:0097284) [is_a relation] is_a  apoptotic process
inflammatory cell apoptotic process (GO:0006925) [is_a relation] is_a  apoptotic process
keratinocyte apoptotic process (GO:0097283) [is_a relation] is_a  apoptotic process
lens fiber cell apoptotic process (GO:1990086) [is_a relation] is_a  apoptotic process
leukocyte apoptotic process (GO:0071887) [is_a relation] is_a  apoptotic process
lymphocyte apoptotic process (GO:0070227) [is_a relation] is_a  apoptotic process
macrophage apoptotic process (GO:0071888) [is_a relation] is_a  apoptotic process
mast cell apoptotic process (GO:0033024) [is_a relation] is_a  apoptotic process
mature B cell apoptotic process (GO:0002901) [is_a relation] is_a  apoptotic process
melanocyte apoptotic process (GO:1902362) [is_a relation] is_a  apoptotic process
mesenchymal cell apoptotic process (GO:0097152) [is_a relation] is_a  apoptotic process
motor neuron apoptotic process (GO:0097049) [is_a relation] is_a  apoptotic process
muscle cell apoptotic process (GO:0010657) [is_a relation] is_a  apoptotic process
myeloid cell apoptotic process (GO:0033028) [is_a relation] is_a  apoptotic process
myofibroblast cell apoptotic process (GO:1904516) [is_a relation] is_a  apoptotic process
natural killer cell apoptotic process (GO:0070246) [is_a relation] is_a  apoptotic process
negative regulation of apoptotic process (GO:0043066) [negatively_regulates relation] negatively_regulates  apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154) [part_of relation] part_of  apoptotic process
negative regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902109) [part_of relation] part_of  apoptotic process
neuron apoptotic process (GO:0051402) [is_a relation] is_a  apoptotic process
neutrophil apoptotic process (GO:0001781) [is_a relation] is_a  apoptotic process
nurse cell apoptotic process (GO:0045476) [is_a relation] is_a  apoptotic process
oligodendrocyte apoptotic process (GO:0097252) [is_a relation] is_a  apoptotic process
peptidase activator activity involved in apoptotic process (GO:0016505) [part_of relation] part_of  apoptotic process
positive regulation of apoptotic process (GO:0043065) [positively_regulates relation] positively_regulates  apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) [part_of relation] part_of  apoptotic process
positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110) [part_of relation] part_of  apoptotic process
regulation of apoptotic process (GO:0042981) [regulates relation] regulates  apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) [part_of relation] part_of  apoptotic process
regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108) [part_of relation] part_of  apoptotic process
regulatory T cell apoptotic process (GO:1902482) [is_a relation] is_a  apoptotic process
retinal cell apoptotic process (GO:1990009) [is_a relation] is_a  apoptotic process
retinal cone cell apoptotic process (GO:0097474) [is_a relation] is_a  apoptotic process
retinal rod cell apoptotic process (GO:0097473) [is_a relation] is_a  apoptotic process
Sertoli cell apoptotic process (GO:1902484) [is_a relation] is_a  apoptotic process
smooth muscle cell apoptotic process (GO:0034390) [is_a relation] is_a  apoptotic process
striated muscle cell apoptotic process (GO:0010658) [is_a relation] is_a  apoptotic process
T cell apoptotic process (GO:0070231) [is_a relation] is_a  apoptotic process
thymocyte apoptotic process (GO:0070242) [is_a relation] is_a  apoptotic process
type B pancreatic cell apoptotic process (GO:0097050) [is_a relation] is_a  apoptotic process