Term Information [More information on glutamate decarboxylation to succinate]

Accession
GO:0006540
Name
glutamate decarboxylation to succinate
Ontology
biological_process
Synonyms
4-aminobutyrate shunt, GABA shunt, degradation of glutamate to succinate through GABA, gamma-aminobutyrate shunt, glutamate degradation via 4-aminobutyrate, glutamate degradation via GABA
Definition
The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. Source: PMID:12740438
Comment
Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively).
History
See term history for GO:0006540 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0006540 from QuickGO

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Ancestors of glutamate decarboxylation to succinate (GO:0006540)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) single-organism metabolic process (GO:0044710)
glutamate decarboxylation to succinate [is_a relation] is_a  catabolic process (GO:0009056)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) small molecule metabolic process (GO:0044281)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organic acid metabolic process (GO:0006082)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) single-organism catabolic process (GO:0044712)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) cellular catabolic process (GO:0044248)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) nitrogen compound metabolic process (GO:0006807)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organic substance catabolic process (GO:1901575)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) oxoacid metabolic process (GO:0043436)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) small molecule catabolic process (GO:0044282)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) carboxylic acid metabolic process (GO:0019752)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organic acid catabolic process (GO:0016054)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organonitrogen compound metabolic process (GO:1901564)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) carboxylic acid catabolic process (GO:0046395)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) cellular amino acid metabolic process (GO:0006520)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) organonitrogen compound catabolic process (GO:1901565)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) alpha-amino acid metabolic process (GO:1901605)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) cellular amino acid catabolic process (GO:0009063)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) alpha-amino acid catabolic process (GO:1901606)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) dicarboxylic acid metabolic process (GO:0043648)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) glutamine family amino acid metabolic process (GO:0009064)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) dicarboxylic acid catabolic process (GO:0043649)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) glutamate metabolic process (GO:0006536)
glutamate decarboxylation to succinate [Inferred is_a relation] is_a (inferred) glutamine family amino acid catabolic process (GO:0009065)
glutamate decarboxylation to succinate [is_a relation] is_a  glutamate catabolic process (GO:0006538)
glutamate decarboxylation to succinate [is_a relation] is_a  succinate metabolic process (GO:0006105)
Children of glutamate decarboxylation to succinate (GO:0006540)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity (GO:0036242) [is_a relation] is_a  glutamate decarboxylation to succinate
glutamate catabolic process to succinate via succinate semialdehyde (GO:0019549) [is_a relation] is_a  glutamate decarboxylation to succinate