Term Information [More information on apoptotic DNA fragmentation]

Accession
GO:0006309
Name
apoptotic DNA fragmentation
Ontology
biological_process
Synonyms
alt. id: GO:0008178
DNA catabolic process during apoptosis, DNA catabolism during apoptosis, DNA fragmentation involved in apoptotic nuclear change, endonucleolytic DNA catabolic process involved in apoptosis, DNA fragmentation, chromatinolysis
Definition
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. Source: GOC:dph, GOC:tb, PMID:23379520, ISBN:0721639976, GOC:mtg_apoptosis, GOC:mah, PMID:15723341
Comment
DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
History
See term history for GO:0006309 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0006309 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of apoptotic DNA fragmentation (GO:0006309)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) death (GO:0016265)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) nitrogen compound metabolic process (GO:0006807)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) catabolic process (GO:0009056)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular aromatic compound metabolic process (GO:0006725)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular nitrogen compound metabolic process (GO:0034641)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) heterocycle metabolic process (GO:0046483)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) organic cyclic compound metabolic process (GO:1901360)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular catabolic process (GO:0044248)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cellular component organization or biogenesis (GO:0071840)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) nucleobase-containing compound metabolic process (GO:0006139)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) organic substance catabolic process (GO:1901575)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) apoptotic process (GO:0006915)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) aromatic compound catabolic process (GO:0019439)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cellular component organization (GO:0016043)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular nitrogen compound catabolic process (GO:0044270)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) heterocycle catabolic process (GO:0046700)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) macromolecule catabolic process (GO:0009057)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) nucleic acid metabolic process (GO:0090304)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) organic cyclic compound catabolic process (GO:1901361)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cellular component disassembly (GO:0022411)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) cellular macromolecule catabolic process (GO:0044265)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) DNA metabolic process (GO:0006259)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) execution phase of apoptosis (GO:0097194)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) nucleobase-containing compound catabolic process (GO:0034655)
apoptotic DNA fragmentation [Inferred part_of relation] part_of (inferred) cellular component disassembly involved in execution phase of apoptosis (GO:0006921)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) DNA catabolic process (GO:0006308)
apoptotic DNA fragmentation [Inferred is_a relation] is_a (inferred) nucleic acid phosphodiester bond hydrolysis (GO:0090305)
apoptotic DNA fragmentation [part_of relation] part_of  apoptotic nuclear changes (GO:0030262)
apoptotic DNA fragmentation [is_a relation] is_a  DNA catabolic process, endonucleolytic (GO:0000737)
Children of apoptotic DNA fragmentation (GO:0006309)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of apoptotic DNA fragmentation (GO:1902511) [negatively_regulates relation] negatively_regulates  apoptotic DNA fragmentation
positive regulation of apoptotic DNA fragmentation (GO:1902512) [positively_regulates relation] positively_regulates  apoptotic DNA fragmentation
regulation of apoptotic DNA fragmentation (GO:1902510) [regulates relation] regulates  apoptotic DNA fragmentation