Term Information [More information on mitochondrial pyruvate dehydrogenase complex]

Accession
GO:0005967
Name
mitochondrial pyruvate dehydrogenase complex
Ontology
cellular_component
Synonyms
pyruvate dehydrogenase complex (lipoamide)
Definition
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. Source: ISBN:0716720094, ISBN:0471331309, GOC:mtg_sensu
Comment
Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
History
See term history for GO:0005967 at QuickGO
Subset
None
Community
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Graph of GO:0005967 from QuickGO

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Ancestors of mitochondrial pyruvate dehydrogenase complex (GO:0005967)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) metabolic process (GO:0008152)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism process (GO:0044699)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular process (GO:0009987)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism metabolic process (GO:0044710)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) biosynthetic process (GO:0009058)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular metabolic process (GO:0044237)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) organic substance metabolic process (GO:0071704)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism cellular process (GO:0044763)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) small molecule metabolic process (GO:0044281)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular biosynthetic process (GO:0044249)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) cofactor metabolic process (GO:0051186)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) molecular_function (GO:0003674)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) organic acid metabolic process (GO:0006082)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) sulfur compound metabolic process (GO:0006790)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) catalytic activity (GO:0003824)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) coenzyme metabolic process (GO:0006732)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) cofactor biosynthetic process (GO:0051188)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) organic substance biosynthetic process (GO:1901576)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) oxidation-reduction process (GO:0055114)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) oxoacid metabolic process (GO:0043436)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) phosphorus metabolic process (GO:0006793)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) sulfur compound biosynthetic process (GO:0044272)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) thioester metabolic process (GO:0035383)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) acyl-CoA metabolic process (GO:0006637)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) carboxylic acid metabolic process (GO:0019752)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) coenzyme biosynthetic process (GO:0009108)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) organelle (GO:0043226)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of relation] capable_of (inferred) oxidoreductase activity (GO:0016491)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) thioester biosynthetic process (GO:0035384)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) acetyl-CoA metabolic process (GO:0006084)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) acyl-CoA biosynthetic process (GO:0071616)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular organelle (GO:0043229)
mitochondrial pyruvate dehydrogenase complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) membrane-bounded organelle (GO:0043227)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) monocarboxylic acid metabolic process (GO:0032787)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of relation] capable_of (inferred) oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) acetyl-CoA biosynthetic process (GO:0006085)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) cytoplasmic part (GO:0044444)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular membrane-bounded organelle (GO:0043231)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) membrane-enclosed lumen (GO:0031974)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) organelle part (GO:0044422)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)
mitochondrial pyruvate dehydrogenase complex [Inferred is_a relation] is_a (inferred) protein complex (GO:0043234)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) pyruvate dehydrogenase activity (GO:0004738)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) pyruvate metabolic process (GO:0006090)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) single-organism biosynthetic process (GO:0044711)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) acetyl-CoA biosynthetic process from pyruvate (GO:0006086)
mitochondrial pyruvate dehydrogenase complex [Inferred is_a relation] is_a (inferred) catalytic complex (GO:1902494)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular organelle part (GO:0044446)
mitochondrial pyruvate dehydrogenase complex [part_of relation] part_of  mitochondrion (GO:0005739)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) organelle lumen (GO:0043233)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of relation] capable_of (inferred) pyruvate dehydrogenase [NAD(P)+] activity (GO:0034603)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) intracellular organelle lumen (GO:0070013)
mitochondrial pyruvate dehydrogenase complex [Inferred part_of relation] part_of (inferred) mitochondrial part (GO:0044429)
mitochondrial pyruvate dehydrogenase complex [Inferred is_a relation] is_a (inferred) oxidoreductase complex (GO:1990204)
mitochondrial pyruvate dehydrogenase complex [Inferred capable_of part of relation] capable_of part of (inferred) pyruvate dehydrogenase (NAD+) activity (GO:0034604)
mitochondrial pyruvate dehydrogenase complex [part_of relation] part_of  mitochondrial matrix (GO:0005759)
mitochondrial pyruvate dehydrogenase complex [is_a relation] is_a  mitochondrial protein complex (GO:0098798)
mitochondrial pyruvate dehydrogenase complex [is_a relation] is_a  pyruvate dehydrogenase complex (GO:0045254)

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