Term Information [More information on Rho guanyl-nucleotide exchange factor activity]

Accession
GO:0005089
Name
Rho guanyl-nucleotide exchange factor activity
Ontology
molecular_function
Synonyms
Rho guanine nucleotide exchange factor, RhoGEF
Definition
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Source: GOC:mah
Comment
None
History
See term history for GO:0005089 at QuickGO
Subset
goslim_chembl
Community
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Feedback
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Graph of GO:0005089 from QuickGO

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Ancestors of Rho guanyl-nucleotide exchange factor activity (GO:0005089)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) metabolic process (GO:0008152)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) molecular_function (GO:0003674)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) catalytic activity (GO:0003824)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) binding (GO:0005488)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity (GO:0016787)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) biological regulation (GO:0065007)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) heterocyclic compound binding (GO:1901363)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity, acting on acid anhydrides (GO:0016817)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) organic cyclic compound binding (GO:0097159)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleoside phosphate binding (GO:1901265)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of biological process (GO:0050789)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) small molecule binding (GO:0036094)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) carbohydrate derivative binding (GO:0097367)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleotide binding (GO:0000166)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of biological process (GO:0048518)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) pyrophosphatase activity (GO:0016462)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of metabolic process (GO:0019222)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of molecular function (GO:0065009)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleoside binding (GO:0001882)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) nucleoside-triphosphatase activity (GO:0017111)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of metabolic process (GO:0009893)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of molecular function (GO:0044093)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine nucleotide binding (GO:0017076)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of catalytic activity (GO:0050790)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ribonucleotide binding (GO:0032553)
Rho guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) GTPase activity (GO:0003924)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) guanyl nucleotide binding (GO:0019001)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ion binding (GO:0043167)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of catalytic activity (GO:0043085)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine nucleoside binding (GO:0001883)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine ribonucleotide binding (GO:0032555)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of hydrolase activity (GO:0051336)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ribonucleoside binding (GO:0032549)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) anion binding (GO:0043168)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) guanyl ribonucleotide binding (GO:0032561)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of hydrolase activity (GO:0051345)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine ribonucleoside binding (GO:0032550)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of GTPase activity (GO:0043087)
Rho guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) GDP binding (GO:0019003)
Rho guanyl-nucleotide exchange factor activity [Inferred is_a relation] is_a (inferred) molecular function regulator (GO:0098772)
Rho guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of GTPase activity (GO:0043547)
Rho guanyl-nucleotide exchange factor activity [Inferred is_a relation] is_a (inferred) guanyl-nucleotide exchange factor activity (GO:0005085)
Rho guanyl-nucleotide exchange factor activity [is_a relation] is_a  Ras guanyl-nucleotide exchange factor activity (GO:0005088)
Children of Rho guanyl-nucleotide exchange factor activity (GO:0005089)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of Rho guanyl-nucleotide exchange factor activity (GO:2001107) [negatively_regulates relation] negatively_regulates  Rho guanyl-nucleotide exchange factor activity
positive regulation of Rho guanyl-nucleotide exchange factor activity (GO:2001108) [positively_regulates relation] positively_regulates  Rho guanyl-nucleotide exchange factor activity
Rac guanyl-nucleotide exchange factor activity (GO:0030676) [is_a relation] is_a  Rho guanyl-nucleotide exchange factor activity
regulation of Rho guanyl-nucleotide exchange factor activity (GO:2001106) [regulates relation] regulates  Rho guanyl-nucleotide exchange factor activity