Term Information [More information on guanyl-nucleotide exchange factor activity]

Accession
GO:0005085
Name
guanyl-nucleotide exchange factor activity
Ontology
molecular_function
Synonyms
alt. id: GO:0019839, GO:0016219, GO:0008433
GDP-dissociation stimulator activity, GDS, GEF, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor, GNRP
Definition
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Source: GOC:kd, GOC:mah
Comment
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
History
See term history for GO:0005085 at QuickGO
Subset
gosubset_prok
goslim_chembl
goslim_yeast
Community
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Feedback
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Contacting server...
View this term in QuickGO.

Graph of GO:0005085 from QuickGO

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Ancestors of guanyl-nucleotide exchange factor activity (GO:0005085)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) molecular_function (GO:0003674)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) catalytic activity (GO:0003824)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) binding (GO:0005488)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity (GO:0016787)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) heterocyclic compound binding (GO:1901363)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity, acting on acid anhydrides (GO:0016817)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) organic cyclic compound binding (GO:0097159)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) biological regulation (GO:0065007)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleoside phosphate binding (GO:1901265)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) small molecule binding (GO:0036094)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) carbohydrate derivative binding (GO:0097367)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleotide binding (GO:0000166)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) pyrophosphatase activity (GO:0016462)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of molecular function (GO:0065009)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) nucleoside binding (GO:0001882)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) nucleoside-triphosphatase activity (GO:0017111)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of molecular function (GO:0044093)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine nucleotide binding (GO:0017076)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of catalytic activity (GO:0050790)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ribonucleotide binding (GO:0032553)
guanyl-nucleotide exchange factor activity [Inferred related_to relation] related_to (inferred) GTPase activity (GO:0003924)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) guanyl nucleotide binding (GO:0019001)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ion binding (GO:0043167)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of catalytic activity (GO:0043085)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine nucleoside binding (GO:0001883)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine ribonucleotide binding (GO:0032555)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of hydrolase activity (GO:0051336)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) ribonucleoside binding (GO:0032549)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) anion binding (GO:0043168)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) guanyl ribonucleotide binding (GO:0032561)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) positive regulation of hydrolase activity (GO:0051345)
guanyl-nucleotide exchange factor activity [Inferred negatively_regulates relation] negatively_regulates (inferred) purine ribonucleoside binding (GO:0032550)
guanyl-nucleotide exchange factor activity [Inferred part_of relation] part_of (inferred) regulation of GTPase activity (GO:0043087)
guanyl-nucleotide exchange factor activity [negatively_regulates relation] negatively_regulates  GDP binding (GO:0019003)
guanyl-nucleotide exchange factor activity [is_a relation] is_a  molecular function regulator (GO:0098772)
guanyl-nucleotide exchange factor activity [part_of relation] part_of  positive regulation of GTPase activity (GO:0043547)
Children of guanyl-nucleotide exchange factor activity (GO:0005085)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ARF guanyl-nucleotide exchange factor activity (GO:0005086) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity (GO:0017132) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
guanyl-nucleotide exchange factor complex (GO:0032045) [capable_of relation] capable_of  guanyl-nucleotide exchange factor activity
negative regulation of guanyl-nucleotide exchange factor activity (GO:1905098) [negatively_regulates relation] negatively_regulates  guanyl-nucleotide exchange factor activity
positive regulation of guanyl-nucleotide exchange factor activity (GO:1905099) [positively_regulates relation] positively_regulates  guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity (GO:0005088) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
regulation of guanyl-nucleotide exchange factor activity (GO:1905097) [regulates relation] regulates  guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity (GO:0005090) [is_a relation] is_a  guanyl-nucleotide exchange factor activity
Reactome
REACT_78375
REACT_77041
REACT_80694
REACT_82999
REACT_44918
REACT_113598
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