Term Information [More information on scavenger receptor activity]

Accession
GO:0005044
Name
scavenger receptor activity
Ontology
molecular_function
Synonyms
macrophage receptor activity
Definition
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Source: PMID:12621157, PMID:11790542, GOC:bf, PMID:12379907, PMID:20981357
Comment
Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
History
See term history for GO:0005044 at QuickGO
Subset
gosubset_prok
goslim_chembl
Community
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Feedback
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Graph of GO:0005044 from QuickGO

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Ancestors of scavenger receptor activity (GO:0005044)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
scavenger receptor activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) localization (GO:0051179)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) establishment of localization (GO:0051234)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) transport (GO:0006810)
scavenger receptor activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) vesicle-mediated transport (GO:0016192)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) endocytosis (GO:0006897)
scavenger receptor activity [Inferred is_a relation] is_a (inferred) molecular transducer activity (GO:0060089)
scavenger receptor activity [Inferred is_a relation] is_a (inferred) receptor activity (GO:0004872)
scavenger receptor activity [Inferred part_of relation] part_of (inferred) receptor-mediated endocytosis (GO:0006898)
scavenger receptor activity [is_a relation] is_a  cargo receptor activity (GO:0038024)

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