Term Information [More information on ureidoglycolate hydrolase activity]

Accession
GO:0004848
Name
ureidoglycolate hydrolase activity
Ontology
molecular_function
Synonyms
(S)-ureidoglycolate amidohydrolase (decarboxylating)
Definition
Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+). Source: RHEA:19812, EC:3.5.3.19
Comment
Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
History
See term history for GO:0004848 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0004848 from QuickGO

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Ancestors of ureidoglycolate hydrolase activity (GO:0004848)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ureidoglycolate hydrolase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
ureidoglycolate hydrolase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
ureidoglycolate hydrolase activity [Inferred is_a relation] is_a (inferred) hydrolase activity (GO:0016787)
ureidoglycolate hydrolase activity [Inferred is_a relation] is_a (inferred) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (GO:0016810)
ureidoglycolate hydrolase activity [is_a relation] is_a  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813)

This term has no children.

EC
3.5.3.19
KEGG
R00469
MetaCyc
UREIDOGLYCOLATE-HYDROLASE-RXN
RHEA
19812