Term Information [More information on CAAX-protein geranylgeranyltransferase activity]

Accession
GO:0004662
Name
CAAX-protein geranylgeranyltransferase activity
Ontology
molecular_function
Synonyms
GGTase-I activity, GGTaseI activity, geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity, geranylgeranyltransferase type I activity, type I protein geranyl-geranyltransferase activity, protein geranylgeranyltransferase type I
Definition
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. Source: EC:2.5.1.59, PMID:8621375
Comment
None
History
See term history for GO:0004662 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0004662 from QuickGO

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Ancestors of CAAX-protein geranylgeranyltransferase activity (GO:0004662)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity (GO:0016740)
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) prenyltransferase activity (GO:0004659)
CAAX-protein geranylgeranyltransferase activity [Inferred is_a relation] is_a (inferred) protein prenyltransferase activity (GO:0008318)
CAAX-protein geranylgeranyltransferase activity [is_a relation] is_a  protein geranylgeranyltransferase activity (GO:0004661)
Children of CAAX-protein geranylgeranyltransferase activity (GO:0004662)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CAAX-protein geranylgeranyltransferase complex (GO:0005953) [capable_of relation] capable_of  CAAX-protein geranylgeranyltransferase activity