Term Information [More information on methylenetetrahydrofolate reductase (NAD(P)H) activity]

Accession
GO:0004489
Name
methylenetetrahydrofolate reductase (NAD(P)H) activity
Ontology
molecular_function
Synonyms
alt. id: GO:0008702
5,10-CH(2)-H(4)folate reductase activity, 5,10-CH2-H4folate reductase activity, 5,10-methylenetetrahydrofolate reductase (FADH) activity, 5,10-methylenetetrahydrofolate reductase (FADH2) activity, 5,10-methylenetetrahydrofolate reductase (NADPH) activity, 5,10-methylenetetrahydropteroylglutamate reductase activity, 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity, 5-methyltetrahydrofolate:NAD oxidoreductase activity, 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity, 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity, 5-methyltetrahydrofolate:NAD+ oxidoreductase activity, 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity, 5-methyltetrahydrofolate:NADP+ oxidoreductase activity, N5,10-methylenetetrahydrofolate reductase activity, N5,N10-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity, methylenetetrahydrofolate reductase (NADPH(2)) activity, methylenetetrahydrofolate reductase (NADPH2), 1.7.99.5, 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity, MetF, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity, methylenetetrahydrofolate reductase [NAD(P)H], 5,10-methylenetetrahydrofolate reductase activity, 5,10-methylenetetrahydrofolic acid reductase activity, MTHFR activity, N(5),N(10)-methylenetetrahydrofolate reductase activity, N(5,10)-methylenetetrahydrofolate reductase activity, methylenetetrahydrofolate reductase activity, methylenetetrahydrofolic acid reductase activity
Definition
Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. Source: EC:1.5.1.20
Comment
Includes EC 1.7.99.5.
History
See term history for GO:0004489 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Contacting server...
View this term in QuickGO.

Graph of GO:0004489 from QuickGO

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Ancestors of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred part_of relation] part_of (inferred) single-organism metabolic process (GO:0044710)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred part_of relation] part_of (inferred) oxidation-reduction process (GO:0055114)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred is_a relation] is_a (inferred) oxidoreductase activity (GO:0016491)
methylenetetrahydrofolate reductase (NAD(P)H) activity [Inferred is_a relation] is_a (inferred) oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645)
methylenetetrahydrofolate reductase (NAD(P)H) activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)
Children of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:0004489)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903869) [negatively_regulates relation] negatively_regulates  methylenetetrahydrofolate reductase (NAD(P)H) activity
positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903870) [positively_regulates relation] positively_regulates  methylenetetrahydrofolate reductase (NAD(P)H) activity
regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity (GO:1903868) [regulates relation] regulates  methylenetetrahydrofolate reductase (NAD(P)H) activity