Term Information [More information on serine-type endopeptidase activity]

Accession
GO:0004252
Name
serine-type endopeptidase activity
Ontology
molecular_function
Synonyms
blood coagulation factor activity, serine elastase activity
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). Source: ISBN:0716720094, GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE
Comment
None
History
See term history for GO:0004252 at QuickGO
Subset
gosubset_prok
goslim_chembl
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0004252 from QuickGO

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Ancestors of serine-type endopeptidase activity (GO:0004252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) organic substance metabolic process (GO:0071704)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) macromolecule metabolic process (GO:0043170)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) primary metabolic process (GO:0044238)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) protein metabolic process (GO:0019538)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) hydrolase activity (GO:0016787)
serine-type endopeptidase activity [Inferred part_of relation] part_of (inferred) proteolysis (GO:0006508)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) peptidase activity (GO:0008233)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) peptidase activity, acting on L-amino acid peptides (GO:0070011)
serine-type endopeptidase activity [Inferred is_a relation] is_a (inferred) serine hydrolase activity (GO:0017171)
serine-type endopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
serine-type endopeptidase activity [is_a relation] is_a  serine-type peptidase activity (GO:0008236)
Children of serine-type endopeptidase activity (GO:0004252)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of serine-type endopeptidase activity (GO:1900004) [negatively_regulates relation] negatively_regulates  serine-type endopeptidase activity
positive regulation of serine-type endopeptidase activity (GO:1900005) [positively_regulates relation] positively_regulates  serine-type endopeptidase activity
regulation of serine-type endopeptidase activity (GO:1900003) [regulates relation] regulates  serine-type endopeptidase activity
serine-type endopeptidase inhibitor activity (GO:0004867) [negatively_regulates relation] negatively_regulates  serine-type endopeptidase activity
EC
3.4.21
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