Term Information [More information on metalloendopeptidase activity]

Accession
GO:0004222
Name
metalloendopeptidase activity
Ontology
molecular_function
Synonyms
metalloendoprotease activity, metalloendoproteinase activity
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Source: http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE, GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE
Comment
None
History
See term history for GO:0004222 at QuickGO
Subset
gosubset_prok
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0004222 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) organic substance metabolic process (GO:0071704)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) macromolecule metabolic process (GO:0043170)
metalloendopeptidase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) primary metabolic process (GO:0044238)
metalloendopeptidase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) protein metabolic process (GO:0019538)
metalloendopeptidase activity [Inferred is_a relation] is_a (inferred) hydrolase activity (GO:0016787)
metalloendopeptidase activity [Inferred part_of relation] part_of (inferred) proteolysis (GO:0006508)
metalloendopeptidase activity [Inferred is_a relation] is_a (inferred) peptidase activity (GO:0008233)
metalloendopeptidase activity [Inferred is_a relation] is_a (inferred) peptidase activity, acting on L-amino acid peptides (GO:0070011)
metalloendopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
metalloendopeptidase activity [is_a relation] is_a  metallopeptidase activity (GO:0008237)
Children of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metalloendopeptidase activity involved in amyloid precursor protein catabolic process (GO:1902945) [is_a relation] is_a  metalloendopeptidase activity
metalloendopeptidase inhibitor activity (GO:0008191) [negatively_regulates relation] negatively_regulates  metalloendopeptidase activity
negative regulation of metalloendopeptidase activity (GO:1904684) [negatively_regulates relation] negatively_regulates  metalloendopeptidase activity
positive regulation of metalloendopeptidase activity (GO:1904685) [positively_regulates relation] positively_regulates  metalloendopeptidase activity
regulation of metalloendopeptidase activity (GO:1904683) [regulates relation] regulates  metalloendopeptidase activity