Term Information [More information on dihydrofolate reductase activity]

Accession
GO:0004146
Name
dihydrofolate reductase activity
Ontology
molecular_function
Synonyms
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity, 7,8-dihydrofolate reductase activity, NADPH-dihydrofolate reductase activity, dihydrofolate reductase:thymidylate synthase activity, dihydrofolate reduction, dihydrofolic acid reductase activity, dihydrofolic reductase activity, folic acid reductase activity, folic reductase activity, pteridine reductase:dihydrofolate reductase activity, tetrahydrofolate dehydrogenase activity, thymidylate synthetase-dihydrofolate reductase activity, DHFR
Definition
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. Source: EC:1.5.1.3
Comment
None
History
See term history for GO:0004146 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0004146 from QuickGO

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Ancestors of dihydrofolate reductase activity (GO:0004146)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
dihydrofolate reductase activity [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
dihydrofolate reductase activity [Inferred part_of relation] part_of (inferred) metabolic process (GO:0008152)
dihydrofolate reductase activity [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
dihydrofolate reductase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
dihydrofolate reductase activity [Inferred part_of relation] part_of (inferred) single-organism metabolic process (GO:0044710)
dihydrofolate reductase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
dihydrofolate reductase activity [Inferred part_of relation] part_of (inferred) oxidation-reduction process (GO:0055114)
dihydrofolate reductase activity [Inferred is_a relation] is_a (inferred) oxidoreductase activity (GO:0016491)
dihydrofolate reductase activity [Inferred is_a relation] is_a (inferred) oxidoreductase activity, acting on the CH-NH group of donors (GO:0016645)
dihydrofolate reductase activity [is_a relation] is_a  oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor (GO:0016646)

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