Term Information [More information on gamma-glutamyltransferase activity]

Accession
GO:0003840
Name
gamma-glutamyltransferase activity
Ontology
molecular_function
Synonyms
(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity, L-gamma-glutamyl transpeptidase activity, L-gamma-glutamyltransferase activity, L-glutamyltransferase activity, alpha-glutamyl transpeptidase activity, gamma-glutamyl peptidyltransferase activity, gamma-glutamyl transpeptidase activity, glutamyl transpeptidase activity, gamma-GPT, gamma-GT, gamma-GTP
Definition
Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. Source: EC:2.3.2.2
Comment
The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity).
History
See term history for GO:0003840 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0003840 from QuickGO

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Ancestors of gamma-glutamyltransferase activity (GO:0003840)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity (GO:0016740)
gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity, transferring acyl groups (GO:0016746)
gamma-glutamyltransferase activity [is_a relation] is_a  transferase activity, transferring amino-acyl groups (GO:0016755)

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