Term Information [More information on protein-glutamine gamma-glutamyltransferase activity]

Accession
GO:0003810
Name
protein-glutamine gamma-glutamyltransferase activity
Ontology
molecular_function
Synonyms
R-glutaminyl-peptide:amine gamma-glutamyl transferase activity, TGase activity, fibrinoligase activity, glutaminylpeptide gamma-glutamyltransferase activity, protein-glutamine:amine gamma-glutamyltransferase, transglutaminase activity, factor XIIIa, fibrin stabilizing factor, polyamine transglutaminase activity, tissue transglutaminase
Definition
Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. Source: RESID:AA0124, EC:2.3.2.13
Comment
None
History
See term history for GO:0003810 at QuickGO
Subset
gosubset_prok
Community
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Feedback
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Graph of GO:0003810 from QuickGO

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Ancestors of protein-glutamine gamma-glutamyltransferase activity (GO:0003810)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein-glutamine gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
protein-glutamine gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
protein-glutamine gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity (GO:0016740)
protein-glutamine gamma-glutamyltransferase activity [Inferred is_a relation] is_a (inferred) transferase activity, transferring acyl groups (GO:0016746)
protein-glutamine gamma-glutamyltransferase activity [is_a relation] is_a  transferase activity, transferring amino-acyl groups (GO:0016755)

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