Term Information [More information on sphingosine-1-phosphate signaling pathway]

Accession
GO:0003376
Name
sphingosine-1-phosphate signaling pathway
Ontology
biological_process
Synonyms
S1P receptor signaling pathway, S1P signaling pathway, S1P-activated G-protein coupled receptor signaling pathway, S1P-activated GPCR signaling pathway, S1P-stimulated signal transduction pathway, sphingosine-1-phosphate signal transduction, sphingolipid signaling pathway, sphingolipid signalling pathway
Definition
A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. Source: GOC:ascb_2009, GOC:signaling, PMID:22001186, Reactome:REACT_18416.2
Comment
Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
History
See term history for GO:0003376 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0003376 from QuickGO

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Ancestors of sphingosine-1-phosphate signaling pathway (GO:0003376)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
sphingosine-1-phosphate signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
sphingosine-1-phosphate signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
sphingosine-1-phosphate signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
sphingosine-1-phosphate signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
sphingosine-1-phosphate signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
sphingosine-1-phosphate signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
sphingosine-1-phosphate signaling pathway [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
sphingosine-1-phosphate signaling pathway [is_a relation] is_a  G-protein coupled receptor signaling pathway (GO:0007186)
sphingosine-1-phosphate signaling pathway [is_a relation] is_a  sphingolipid mediated signaling pathway (GO:0090520)
Children of sphingosine-1-phosphate signaling pathway (GO:0003376)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of apoptosis by sphingosine-1-phosphate signaling pathway (GO:0003377) [is_a relation] is_a  sphingosine-1-phosphate signaling pathway
regulation of inflammatory response by sphingosine-1-phosphate signaling pathway (GO:0003378) [is_a relation] is_a  sphingosine-1-phosphate signaling pathway
sphingosine-1-phosphate receptor activity (GO:0038036) [part_of relation] part_of  sphingosine-1-phosphate signaling pathway
Reactome
REACT_18416.2