Term Information [More information on germinal center B cell differentiation]

Accession
GO:0002314
Name
germinal center B cell differentiation
Ontology
biological_process
Synonyms
germinal center B lymphocyte differentiation, germinal center B-cell differentiation, germinal center B-lymphocyte differentiation, germinal center B cell development
Definition
The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). Source: GOC:jal, ISBN:0781735149
Comment
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History
See term history for GO:0002314 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0002314 from QuickGO

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Ancestors of germinal center B cell differentiation (GO:0002314)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) developmental process (GO:0032502)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) multicellular organismal process (GO:0032501)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) single-multicellular organism process (GO:0044707)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) single-organism developmental process (GO:0044767)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) anatomical structure development (GO:0048856)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) multicellular organismal development (GO:0007275)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) immune system process (GO:0002376)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) system development (GO:0048731)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) animal organ development (GO:0048513)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) immune system development (GO:0002520)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) cell activation (GO:0001775)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) cellular developmental process (GO:0048869)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) hematopoietic or lymphoid organ development (GO:0048534)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
germinal center B cell differentiation [is_a relation] is_a  cell differentiation (GO:0030154)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) hemopoiesis (GO:0030097)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) immune effector process (GO:0002252)
germinal center B cell differentiation [Inferred part_of relation] part_of (inferred) immune response (GO:0006955)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) leukocyte activation (GO:0045321)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) cell activation involved in immune response (GO:0002263)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) leukocyte differentiation (GO:0002521)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) lymphocyte activation (GO:0046649)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) B cell activation (GO:0042113)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) leukocyte activation involved in immune response (GO:0002366)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) lymphocyte differentiation (GO:0030098)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) B cell differentiation (GO:0030183)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) lymphocyte activation involved in immune response (GO:0002285)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) B cell activation involved in immune response (GO:0002312)
germinal center B cell differentiation [Inferred is_a relation] is_a (inferred) mature B cell differentiation (GO:0002335)
germinal center B cell differentiation [is_a relation] is_a  mature B cell differentiation involved in immune response (GO:0002313)

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