Term Information [More information on toll-like receptor signaling pathway]

Accession
GO:0002224
Name
toll-like receptor signaling pathway
Ontology
biological_process
Synonyms
TLR signaling pathway, toll-like receptor signalling pathway
Definition
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. Source: PMID:12524386, PMID:12855817, PMID:15585605, GOC:mtg_15nov05, GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:15728447
Comment
This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
History
See term history for GO:0002224 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0002224 from QuickGO

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Ancestors of toll-like receptor signaling pathway (GO:0002224)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) biological_process (GO:0008150)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) response to stimulus (GO:0050896)
toll-like receptor signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) immune system process (GO:0002376)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of response to stimulus (GO:0048583)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) response to stress (GO:0006950)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) defense response (GO:0006952)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) immune response (GO:0006955)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of biological process (GO:0048518)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of immune system process (GO:0002682)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of response to stress (GO:0080134)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
toll-like receptor signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) innate immune response (GO:0045087)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of immune system process (GO:0002684)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of response to stimulus (GO:0048584)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of defense response (GO:0031347)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of immune response (GO:0050776)
toll-like receptor signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of defense response (GO:0031349)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of immune response (GO:0050778)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) regulation of innate immune response (GO:0045088)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) activation of immune response (GO:0002253)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) immune response-regulating signaling pathway (GO:0002764)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of innate immune response (GO:0045089)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) activation of innate immune response (GO:0002218)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) immune response-activating signal transduction (GO:0002757)
toll-like receptor signaling pathway [Inferred is_a relation] is_a (inferred) innate immune response-activating signal transduction (GO:0002758)
toll-like receptor signaling pathway [is_a relation] is_a  pattern recognition receptor signaling pathway (GO:0002221)
Children of toll-like receptor signaling pathway (GO:0002224)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) [is_a relation] is_a  toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway (GO:0002756) [is_a relation] is_a  toll-like receptor signaling pathway
negative regulation of toll-like receptor signaling pathway (GO:0034122) [negatively_regulates relation] negatively_regulates  toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway (GO:0034123) [positively_regulates relation] positively_regulates  toll-like receptor signaling pathway
regulation of toll-like receptor signaling pathway (GO:0034121) [regulates relation] regulates  toll-like receptor signaling pathway
TIRAP-dependent toll-like receptor signaling pathway (GO:0035664) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 1 signaling pathway (GO:0034130) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 10 signaling pathway (GO:0034166) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 11 signaling pathway (GO:0034170) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 12 signaling pathway (GO:0034174) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 13 signaling pathway (GO:0034178) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 15 signaling pathway (GO:0035681) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 2 signaling pathway (GO:0034134) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 21 signaling pathway (GO:0035682) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 3 signaling pathway (GO:0034138) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway (GO:0034142) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 5 signaling pathway (GO:0034146) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 6 signaling pathway (GO:0034150) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 7 signaling pathway (GO:0034154) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 8 signaling pathway (GO:0034158) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway (GO:0034162) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123) [is_a relation] is_a  toll-like receptor signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124) [is_a relation] is_a  toll-like receptor signaling pathway
Reactome
REACT_25035