Term Information [More information on podosome]

Accession
GO:0002102
Name
podosome
Ontology
cellular_component
Synonyms
None
Definition
An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. Source: PMID:12837608, PMID:15890982
Comment
Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
History
See term history for GO:0002102 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0002102 from QuickGO

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Ancestors of podosome (GO:0002102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
podosome [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
podosome [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
podosome [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
podosome [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
podosome [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
podosome [Inferred part_of relation] part_of (inferred) organelle (GO:0043226)
podosome [Inferred part_of relation] part_of (inferred) intracellular organelle (GO:0043229)
podosome [Inferred part_of relation] part_of (inferred) non-membrane-bounded organelle (GO:0043228)
podosome [Inferred part_of relation] part_of (inferred) intracellular non-membrane-bounded organelle (GO:0043232)
podosome [Inferred is_a relation] is_a (inferred) organelle part (GO:0044422)
podosome [Inferred part_of relation] part_of (inferred) cytoskeleton (GO:0005856)
podosome [Inferred is_a relation] is_a (inferred) intracellular organelle part (GO:0044446)
podosome [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
podosome [part_of relation] part_of  actin cytoskeleton (GO:0015629)
podosome [is_a relation] is_a  cytoskeletal part (GO:0044430)
podosome [is_a relation] is_a  protein complex (GO:0043234)

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Wikipedia
Podosome