Term Information [More information on T cell mediated cytotoxicity]

Accession
GO:0001913
Name
T cell mediated cytotoxicity
Ontology
biological_process
Synonyms
T cell mediated apoptosis, T cell mediated cell death, T cell mediated cell killing, T lymphocyte mediated cytotoxicity, T-cell mediated apoptosis, T-cell mediated cell death, T-cell mediated cell killing, T-cell mediated cytotoxicity, T-lymphocyte mediated cytotoxicity, T cell mediated cytolysis
Definition
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826
Comment
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
History
See term history for GO:0001913 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0001913 from QuickGO

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Ancestors of T cell mediated cytotoxicity (GO:0001913)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune system process (GO:0002376)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) response to stimulus (GO:0050896)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune effector process (GO:0002252)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune response (GO:0006955)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) adaptive immune response (GO:0002250)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) leukocyte mediated immunity (GO:0002443)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)
T cell mediated cytotoxicity [is_a relation] is_a  cell killing (GO:0001906)
T cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) lymphocyte mediated immunity (GO:0002449)
T cell mediated cytotoxicity [is_a relation] is_a  leukocyte mediated cytotoxicity (GO:0001909)
T cell mediated cytotoxicity [is_a relation] is_a  single-organism process (GO:0044699)
T cell mediated cytotoxicity [is_a relation] is_a  T cell mediated immunity (GO:0002456)
Children of T cell mediated cytotoxicity (GO:0001913)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cytotoxic T cell degranulation (GO:0043316) [part_of relation] part_of  T cell mediated cytotoxicity
negative regulation of T cell mediated cytotoxicity (GO:0001915) [negatively_regulates relation] negatively_regulates  T cell mediated cytotoxicity
positive regulation of T cell mediated cytotoxicity (GO:0001916) [positively_regulates relation] positively_regulates  T cell mediated cytotoxicity
regulation of T cell mediated cytotoxicity (GO:0001914) [regulates relation] regulates  T cell mediated cytotoxicity
T cell mediated cytotoxicity directed against tumor cell target (GO:0002419) [is_a relation] is_a  T cell mediated cytotoxicity
None.