Term Information [More information on release of cytochrome c from mitochondria]

Accession
GO:0001836
Name
release of cytochrome c from mitochondria
Ontology
biological_process
Synonyms
None
Definition
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. Source: PMID:12925707, ISBN:0721639976, GOC:mtg_apoptosis, GOC:mah, GOC:add, PMID:9560217
Comment
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
History
See term history for GO:0001836 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0001836 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of release of cytochrome c from mitochondria (GO:0001836)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) biological regulation (GO:0065007)
release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) cellular component organization or biogenesis (GO:0071840)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) cellular component organization (GO:0016043)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) regulation of biological process (GO:0050789)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) organelle organization (GO:0006996)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) regulation of cellular process (GO:0050794)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) apoptotic process (GO:0006915)
release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) mitochondrion organization (GO:0007005)
release of cytochrome c from mitochondria [Inferred part_of relation] part_of (inferred) signal transduction (GO:0007165)
release of cytochrome c from mitochondria [is_a relation] is_a  apoptotic mitochondrial changes (GO:0008637)
release of cytochrome c from mitochondria [part_of relation] part_of  apoptotic signaling pathway (GO:0097190)
Children of release of cytochrome c from mitochondria (GO:0001836)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of release of cytochrome c from mitochondria (GO:0090201) [negatively_regulates relation] negatively_regulates  release of cytochrome c from mitochondria
positive regulation of release of cytochrome c from mitochondria (GO:0090200) [positively_regulates relation] positively_regulates  release of cytochrome c from mitochondria
regulation of release of cytochrome c from mitochondria (GO:0090199) [regulates relation] regulates  release of cytochrome c from mitochondria
None.