Term Information [More information on RNA polymerase II regulatory region sequence-specific DNA binding]

Accession
GO:0000977
Name
RNA polymerase II regulatory region sequence-specific DNA binding
Ontology
molecular_function
Synonyms
None
Definition
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. Source: GOC:txnOH
Comment
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
History
See term history for GO:0000977 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0000977 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) binding (GO:0005488)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) heterocyclic compound binding (GO:1901363)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) organic cyclic compound binding (GO:0097159)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) nucleic acid binding (GO:0003676)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) DNA binding (GO:0003677)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) regulatory region nucleic acid binding (GO:0001067)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) double-stranded DNA binding (GO:0003690)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) regulatory region DNA binding (GO:0000975)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) sequence-specific DNA binding (GO:0043565)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) sequence-specific double-stranded DNA binding (GO:1990837)
RNA polymerase II regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) transcription regulatory region DNA binding (GO:0044212)
RNA polymerase II regulatory region sequence-specific DNA binding [is_a relation] is_a  RNA polymerase II regulatory region DNA binding (GO:0001012)
RNA polymerase II regulatory region sequence-specific DNA binding [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding (GO:0000976)
Children of RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ATF1-ATF4 transcription factor complex (GO:1990590) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
ATF4-CREB1 transcription factor complex (GO:1990589) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
beta-catenin-TCF complex (GO:1990907) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
C/EBP complex (GO:1990647) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
CHOP-ATF4 complex (GO:1990617) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding (GO:1903026) [negatively_regulates relation] negatively_regulates  RNA polymerase II regulatory region sequence-specific DNA binding
regulation of RNA polymerase II regulatory region sequence-specific DNA binding (GO:1903025) [regulates relation] regulates  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (GO:0001162) [is_a relation] is_a  RNA polymerase II regulatory region sequence-specific DNA binding
upstream stimulatory factor complex (GO:1990378) [capable_of relation] capable_of  RNA polymerase II regulatory region sequence-specific DNA binding
None.