Term Information [More information on transcription regulatory region sequence-specific DNA binding]

Accession
GO:0000976
Name
transcription regulatory region sequence-specific DNA binding
Ontology
molecular_function
Synonyms
None
Definition
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. Source: GOC:txnOH
Comment
The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
History
See term history for GO:0000976 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0000976 from QuickGO

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Ancestors of transcription regulatory region sequence-specific DNA binding (GO:0000976)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) binding (GO:0005488)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) heterocyclic compound binding (GO:1901363)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) organic cyclic compound binding (GO:0097159)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) nucleic acid binding (GO:0003676)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) DNA binding (GO:0003677)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) regulatory region nucleic acid binding (GO:0001067)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) double-stranded DNA binding (GO:0003690)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) regulatory region DNA binding (GO:0000975)
transcription regulatory region sequence-specific DNA binding [Inferred is_a relation] is_a (inferred) sequence-specific DNA binding (GO:0043565)
transcription regulatory region sequence-specific DNA binding [is_a relation] is_a  sequence-specific double-stranded DNA binding (GO:1990837)
transcription regulatory region sequence-specific DNA binding [is_a relation] is_a  transcription regulatory region DNA binding (GO:0044212)
Children of transcription regulatory region sequence-specific DNA binding (GO:0000976)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
bacterial-type RNA polymerase regulatory region sequence-specific DNA binding (GO:0000984) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding (GO:0000987) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
core promoter sequence-specific DNA binding (GO:0001046) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
enhancer sequence-specific DNA binding (GO:0001158) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
mitochondrial RNA polymerase regulatory region sequence-specific DNA binding (GO:0001044) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
polymerase III regulatory region sequence-specific DNA binding (GO:0000992) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
transcription termination site sequence-specific DNA binding (GO:0001147) [is_a relation] is_a  transcription regulatory region sequence-specific DNA binding
None.