Term Information [More information on MAPK cascade]

Accession
GO:0000165
Name
MAPK cascade
Ontology
biological_process
Synonyms
MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPKKK cascade, mitogen-activated protein kinase cascade, MAPK signaling, MAPK signalling, ERK/MAPK cascade, MAPKKK cascade during sporulation
Definition
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. Source: PMID:9561267, PMID:20811974, GOC:mtg_signaling_feb11, GOC:bf
Comment
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
History
See term history for GO:0000165 at QuickGO
Subset
None
Community
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Feedback
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Ancestors of MAPK cascade (GO:0000165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MAPK cascade [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
MAPK cascade [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
MAPK cascade [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
MAPK cascade [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
MAPK cascade [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
MAPK cascade [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
MAPK cascade [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
MAPK cascade [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
MAPK cascade [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
MAPK cascade [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
MAPK cascade [Inferred is_a relation] is_a (inferred) macromolecule modification (GO:0043412)
MAPK cascade [Inferred is_a relation] is_a (inferred) phosphorus metabolic process (GO:0006793)
MAPK cascade [Inferred is_a relation] is_a (inferred) protein metabolic process (GO:0019538)
MAPK cascade [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
MAPK cascade [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
MAPK cascade [Inferred is_a relation] is_a (inferred) cellular protein metabolic process (GO:0044267)
MAPK cascade [Inferred is_a relation] is_a (inferred) phosphate-containing compound metabolic process (GO:0006796)
MAPK cascade [Inferred is_a relation] is_a (inferred) protein modification process (GO:0036211)
MAPK cascade [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
MAPK cascade [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
MAPK cascade [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
MAPK cascade [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
MAPK cascade [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
MAPK cascade [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
MAPK cascade [Inferred is_a relation] is_a (inferred) cellular protein modification process (GO:0006464)
MAPK cascade [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
MAPK cascade [Inferred is_a relation] is_a (inferred) phosphorylation (GO:0016310)
MAPK cascade [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
MAPK cascade [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
MAPK cascade [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
MAPK cascade [Inferred is_a relation] is_a (inferred) protein phosphorylation (GO:0006468)
MAPK cascade [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
MAPK cascade [Inferred is_a relation] is_a (inferred) single-organism metabolic process (GO:0044710)
MAPK cascade [is_a relation] is_a  intracellular signal transduction (GO:0035556)
MAPK cascade [is_a relation] is_a  signal transduction by protein phosphorylation (GO:0023014)
Children of MAPK cascade (GO:0000165)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERK1 and ERK2 cascade (GO:0070371) [is_a relation] is_a  MAPK cascade
ERK5 cascade (GO:0070375) [is_a relation] is_a  MAPK cascade
MAP kinase activity (GO:0004707) [part_of relation] part_of  MAPK cascade
MAP kinase kinase activity (GO:0004708) [part_of relation] part_of  MAPK cascade
MAP kinase kinase kinase activity (GO:0004709) [part_of relation] part_of  MAPK cascade
MAP kinase kinase kinase kinase activity (GO:0008349) [part_of relation] part_of  MAPK cascade
MAPK cascade involved in ascospore formation (GO:1903695) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in axon regeneration (GO:1903616) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in cell wall organization or biogenesis (GO:0000196) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in conjugation with cellular fusion (GO:0071507) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in innate immune response (GO:0035420) [is_a relation] is_a  MAPK cascade
MAPK cascade involved in osmosensory signaling pathway (GO:0000161) [is_a relation] is_a  MAPK cascade
MAPK import into nucleus (GO:0000189) [part_of relation] part_of  MAPK cascade
negative regulation of MAPK cascade (GO:0043409) [negatively_regulates relation] negatively_regulates  MAPK cascade
positive regulation of MAPK cascade (GO:0043410) [positively_regulates relation] positively_regulates  MAPK cascade
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway (GO:0090080) [positively_regulates relation] positively_regulates  MAPK cascade
regulation of MAPK cascade (GO:0043408) [regulates relation] regulates  MAPK cascade
stress-activated MAPK cascade (GO:0051403) [is_a relation] is_a  MAPK cascade