Term Information [More information on protein complex]

Accession
GO:0043234
Name
protein complex
Ontology
cellular_component
Synonyms
protein-protein complex
Definition
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. Source: GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/
Comment
A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.
History
See term history for GO:0043234 at QuickGO
Subset
gosubset_prok
goslim_generic
goslim_pir
goslim_chembl
Community
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Feedback
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View this term in QuickGO.

Graph of GO:0043234 from QuickGO

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Ancestors of protein complex (GO:0043234)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein complex [Inferred is_a relation] is_a (inferred) cellular_component (GO:0005575)
protein complex [is_a relation] is_a  macromolecular complex (GO:0032991)
Children of protein complex (GO:0043234)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
1,3-beta-D-glucan synthase complex (GO:0000148) [is_a relation] is_a  protein complex
1-alkyl-2-acetylglycerophosphocholine esterase complex (GO:0008247) [is_a relation] is_a  protein complex
2-iminoacetate synthase complex (GO:1902508) [is_a relation] is_a  protein complex
3-isopropylmalate dehydratase complex (GO:0009316) [is_a relation] is_a  protein complex
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex (GO:0017086) [is_a relation] is_a  protein complex
3-methylcrotonyl-CoA carboxylase complex, mitochondrial (GO:0002169) [is_a relation] is_a  protein complex
3-phenylpropionate dioxygenase complex (GO:0009334) [is_a relation] is_a  protein complex
3M complex (GO:1990393) [is_a relation] is_a  protein complex
4-aminobutyrate transaminase complex (GO:0032144) [is_a relation] is_a  protein complex
5-lipoxygenase complex (GO:0002180) [is_a relation] is_a  protein complex
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex (GO:0043540) [is_a relation] is_a  protein complex
6-phosphofructokinase complex (GO:0005945) [is_a relation] is_a  protein complex
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex (GO:0044673) [is_a relation] is_a  protein complex
ABIN2-NFKB1-MAP3K8 complex (GO:0034977) [is_a relation] is_a  protein complex
acetate CoA-transferase complex (GO:0009329) [is_a relation] is_a  protein complex
acetolactate synthase complex (GO:0005948) [is_a relation] is_a  protein complex
acetyl-CoA carboxylase complex (GO:0009317) [is_a relation] is_a  protein complex
acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex (GO:0044672) [is_a relation] is_a  protein complex
acetyltransferase complex (GO:1902493) [is_a relation] is_a  protein complex
acid phosphatase complex (GO:1904097) [is_a relation] is_a  protein complex
activated SUMO-E1 ligase complex (GO:1990354) [is_a relation] is_a  protein complex
activin complex (GO:0048180) [is_a relation] is_a  protein complex
activin receptor complex (GO:0048179) [is_a relation] is_a  protein complex
acyl-CoA ceramide synthase complex (GO:0061576) [is_a relation] is_a  protein complex
adenylyltransferase complex (GO:1902503) [is_a relation] is_a  protein complex
ADPG pyrophosphorylase complex (GO:0030929) [is_a relation] is_a  protein complex
adrenomedullin receptor complex (GO:1903143) [is_a relation] is_a  protein complex
AIP1-IRE1 complex (GO:1990597) [is_a relation] is_a  protein complex
alkanesulfonate monooxygenase complex (GO:1990201) [is_a relation] is_a  protein complex
alkyl hydroperoxide reductase complex (GO:0009321) [is_a relation] is_a  protein complex
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) (GO:0005946) [is_a relation] is_a  protein complex
alpha-1,6-mannosyltransferase complex (GO:0000136) [is_a relation] is_a  protein complex
alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex (GO:0061694) [is_a relation] is_a  protein complex
alpha1-beta1 integrin-alpha3(VI) complex (GO:0070465) [is_a relation] is_a  protein complex
alpha1-beta1 integrin-tissue transglutaminase complex (GO:0071091) [is_a relation] is_a  protein complex
alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex (GO:0071124) [is_a relation] is_a  protein complex
alpha11-beta1 integrin-collagen type I complex (GO:0071087) [is_a relation] is_a  protein complex
alpha2-beta1 integrin-alpha3(VI) complex (GO:0070466) [is_a relation] is_a  protein complex
alpha2-beta1 integrin-CD47 complex (GO:0071084) [is_a relation] is_a  protein complex
alpha2-beta1 integrin-chondroadherin complex (GO:0071079) [is_a relation] is_a  protein complex
alpha3-beta1 integrin-basigin complex (GO:0071080) [is_a relation] is_a  protein complex
alpha3-beta1 integrin-CD151 complex (GO:0071058) [is_a relation] is_a  protein complex
alpha3-beta1 integrin-CD63 complex (GO:0071081) [is_a relation] is_a  protein complex
alpha3-beta1 integrin-thrombospondin complex (GO:0071095) [is_a relation] is_a  protein complex
alpha3-beta1 integrin-tissue transglutaminase complex (GO:0071092) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-CD47 complex (GO:0071120) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-CD53 complex (GO:0070518) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-CD63 complex (GO:0070519) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-CD81 complex (GO:0070520) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-CD82 complex (GO:0070521) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-JAM2 complex (GO:0071101) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-paxillin complex (GO:0071102) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-thrombospondin-1 complex (GO:0071069) [is_a relation] is_a  protein complex
alpha4-beta1 integrin-thrombospondin-2 complex (GO:0071070) [is_a relation] is_a  protein complex
alpha4-beta4 integrin-EMILIN-1 complex (GO:0071112) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-endostatin complex (GO:0071115) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-fibronectin-NOV complex (GO:0071117) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex (GO:0071093) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-LPP3 complex (GO:0071130) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-osteopontin complex (GO:0071128) [is_a relation] is_a  protein complex
alpha5-beta1 integrin-tissue transglutaminase complex (GO:0071088) [is_a relation] is_a  protein complex
alpha5-beta5-fibronectin-SFRP2 complex (GO:0071138) [is_a relation] is_a  protein complex
alpha6-beta1 integrin-CD151 complex (GO:0071059) [is_a relation] is_a  protein complex
alpha6-beta1 integrin-CYR61 complex (GO:0071116) [is_a relation] is_a  protein complex
alpha6-beta4 integrin-CD151 complex (GO:0071061) [is_a relation] is_a  protein complex
alpha6-beta4 integrin-CD9 complex (GO:0071094) [is_a relation] is_a  protein complex
alpha6-beta4 integrin-Fyn complex (GO:0071098) [is_a relation] is_a  protein complex
alpha6-beta4 integrin-laminin 5 complex (GO:0070334) [is_a relation] is_a  protein complex
alpha6-beta4 integrin-Shc-Grb2 complex (GO:0070333) [is_a relation] is_a  protein complex
alpha7-beta1 integrin-CD151 complex (GO:0071060) [is_a relation] is_a  protein complex
alpha7-beta1 integrin-focal adhesion kinase complex (GO:0071135) [is_a relation] is_a  protein complex
alpha7-beta1 integrin-laminin alpha-2 complex (GO:0071136) [is_a relation] is_a  protein complex
alpha7-beta1 integrin-nicotinamide riboside kinase complex (GO:0071119) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM1 complex (GO:0071052) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM12 complex (GO:0071068) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM15 complex (GO:0071056) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM2 complex (GO:0071053) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM3 complex (GO:0071054) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM8 complex (GO:0071133) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-ADAM9 complex (GO:0071055) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-osteopontin complex (GO:0071127) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-tenascin complex (GO:0071082) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-thrombospondin-1 complex (GO:0071134) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex (GO:0071065) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-VEGF-A complex (GO:0071122) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-VEGF-C complex (GO:0071123) [is_a relation] is_a  protein complex
alpha9-beta1 integrin-VEGF-D complex (GO:0071121) [is_a relation] is_a  protein complex
alphaE-beta7 integrin-E-cadherin complex (GO:0071064) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-CD47-FAK complex (GO:0070770) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-CD47-Src complex (GO:0070771) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-CD9 complex (GO:0071085) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex (GO:0071086) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-CIB complex (GO:0070769) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex (GO:0071090) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-ICAM-4 complex (GO:0071113) [is_a relation] is_a  protein complex
alphaIIb-beta3 integrin-talin complex (GO:0070515) [is_a relation] is_a  protein complex
alphaM-beta2 integrin-CD63 complex (GO:0070558) [is_a relation] is_a  protein complex
alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex (GO:0070719) [is_a relation] is_a  protein complex
alphaPDGFR-SHP-2 complex (GO:0070718) [is_a relation] is_a  protein complex
alphav-beta1 integrin-osteopontin complex (GO:0070030) [is_a relation] is_a  protein complex
alphav-beta3 integrin-ADAM15 complex (GO:0071057) [is_a relation] is_a  protein complex
alphav-beta3 integrin-ADAM23 complex (GO:0071067) [is_a relation] is_a  protein complex
alphav-beta3 integrin-CD47 complex (GO:0070357) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-CD47-FCER2 complex (GO:0071083) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-CD98 complex (GO:0071137) [is_a relation] is_a  protein complex
alphav-beta3 integrin-collagen alpha3(VI) complex (GO:0070464) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-EGFR complex (GO:0071125) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-gelsolin complex (GO:0071096) [is_a relation] is_a  protein complex
alphav-beta3 integrin-HMGB1 complex (GO:0035868) [is_a relation] is_a  protein complex
alphav-beta3 integrin-IGF-1-IGF1R complex (GO:0035867) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-laminin alpha-4 complex (GO:0071131) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-LPP3 complex (GO:0071129) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-NOV complex (GO:0071118) [is_a relation] is_a  protein complex
alphav-beta3 integrin-osteopontin complex (GO:0070029) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-paxillin-Pyk2 complex (GO:0071097) [is_a relation] is_a  protein complex
alphav-beta3 integrin-PKCalpha complex (GO:0035866) [is_a relation] is_a  protein complex
alphav-beta3 integrin-thrombospondin complex (GO:0070017) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-tissue transglutaminase complex (GO:0071089) [is_a relation] is_a  protein complex
alphaV-beta3 integrin-tumstatin complex (GO:0071114) [is_a relation] is_a  protein complex
alphav-beta3 integrin-vitronectin complex (GO:0071062) [is_a relation] is_a  protein complex
alphav-beta5 integrin-osteopontin complex (GO:0070031) [is_a relation] is_a  protein complex
alphav-beta5 integrin-vitronectin complex (GO:0034997) [is_a relation] is_a  protein complex
alphaV-beta6 integrin-osteopontin complex (GO:0071126) [is_a relation] is_a  protein complex
alphaV-beta6 integrin-TGFbeta-3 complex (GO:0071099) [is_a relation] is_a  protein complex
alphaV-beta8 integrin-MMP14-TGFbeta-1 complex (GO:0071100) [is_a relation] is_a  protein complex
alphaX-beta2 integrin-ICAM-4 complex (GO:0071132) [is_a relation] is_a  protein complex
amino acid transport complex (GO:1990184) [is_a relation] is_a  protein complex
aminoacyl-tRNA synthetase multienzyme complex (GO:0017101) [is_a relation] is_a  protein complex
aminodeoxychorismate synthase complex (GO:0009356) [is_a relation] is_a  protein complex
AMPA glutamate receptor complex (GO:0032281) [is_a relation] is_a  protein complex
amylin receptor complex (GO:1903440) [is_a relation] is_a  protein complex
anaerobic ribonucleoside-triphosphate reductase complex (GO:0031250) [is_a relation] is_a  protein complex
angiogenin-PRI complex (GO:0032311) [is_a relation] is_a  protein complex
anthranilate synthase complex (GO:0005950) [is_a relation] is_a  protein complex
AnxA2-p11 complex (GO:1990665) [is_a relation] is_a  protein complex
AP-type membrane coat adaptor complex (GO:0030119) [is_a relation] is_a  protein complex
APC-IQGAP complex (GO:0034743) [is_a relation] is_a  protein complex
APC-IQGAP1-Cdc42 complex (GO:0034744) [is_a relation] is_a  protein complex
APC-IQGAP1-CLIP-170 complex (GO:0034746) [is_a relation] is_a  protein complex
APC-IQGAP1-Rac1 complex (GO:0034745) [is_a relation] is_a  protein complex
APC-tubulin-IQGAP1 complex (GO:0034741) [is_a relation] is_a  protein complex
apolipoprotein B mRNA editing enzyme complex (GO:0030895) [is_a relation] is_a  protein complex
apoptosome (GO:0043293) [is_a relation] is_a  protein complex
Arp2/3 protein complex (GO:0005885) [is_a relation] is_a  protein complex
aryl hydrocarbon receptor complex (GO:0034751) [is_a relation] is_a  protein complex
ASAP complex (GO:0061574) [is_a relation] is_a  protein complex
aspartate carbamoyltransferase complex (GO:0009347) [is_a relation] is_a  protein complex
aster (GO:0005818) [is_a relation] is_a  protein complex
ASTRA complex (GO:0070209) [is_a relation] is_a  protein complex
ATG1/ULK1 kinase complex (GO:1990316) [is_a relation] is_a  protein complex
Atg12-Atg5-Atg16 complex (GO:0034274) [is_a relation] is_a  protein complex
ATP-binding cassette (ABC) transporter complex (GO:0043190) [is_a relation] is_a  protein complex
ATP-sensitive potassium channel complex (GO:0008282) [is_a relation] is_a  protein complex
ATPase complex (GO:1904949) [is_a relation] is_a  protein complex
ATPase dependent transmembrane transport complex (GO:0098533) [is_a relation] is_a  protein complex
ATPase inhibitor complex (GO:1903503) [is_a relation] is_a  protein complex
ATR-ATRIP complex (GO:0070310) [is_a relation] is_a  protein complex
auxin efflux carrier complex (GO:0009921) [is_a relation] is_a  protein complex
axonemal heterotrimeric kinesin-II complex (GO:0030993) [is_a relation] is_a  protein complex
B800-820 antenna complex (GO:0030081) [is_a relation] is_a  protein complex
B800-850 antenna complex (GO:0030082) [is_a relation] is_a  protein complex
B875 antenna complex (GO:0030080) [is_a relation] is_a  protein complex
Bam protein complex (GO:1990063) [is_a relation] is_a  protein complex
BAT3 complex (GO:0071818) [is_a relation] is_a  protein complex
BBSome (GO:0034464) [is_a relation] is_a  protein complex
Bcl-2 family protein complex (GO:0097136) [is_a relation] is_a  protein complex
Bcl3-Bcl10 complex (GO:0032996) [is_a relation] is_a  protein complex
beta-catenin destruction complex (GO:0030877) [is_a relation] is_a  protein complex
beta-galactosidase complex (GO:0009341) [is_a relation] is_a  protein complex
BID-BCL-xl complex (GO:1990346) [is_a relation] is_a  protein complex
biotin carboxylase complex (GO:0009343) [is_a relation] is_a  protein complex
BLOC complex (GO:0031082) [is_a relation] is_a  protein complex
BRCA1-A complex (GO:0070531) [is_a relation] is_a  protein complex
BRCA1-B complex (GO:0070532) [is_a relation] is_a  protein complex
BRCA1-C complex (GO:0070533) [is_a relation] is_a  protein complex
BRCA1-Rad51 complex (GO:0070767) [is_a relation] is_a  protein complex
BRCA2-BRAF35 complex (GO:0002111) [is_a relation] is_a  protein complex
BRCA2-MAGE-D1 complex (GO:0033593) [is_a relation] is_a  protein complex
Bre1-Rad6 ubiquitin ligase complex (GO:1990302) [is_a relation] is_a  protein complex
BRISC complex (GO:0070552) [is_a relation] is_a  protein complex
BtuCD complex (GO:1990193) [is_a relation] is_a  protein complex
bub1-bub3 complex (GO:1990298) [is_a relation] is_a  protein complex
bursicon neuropeptide hormone complex (GO:0031395) [is_a relation] is_a  protein complex
CAAX-protein geranylgeranyltransferase complex (GO:0005953) [is_a relation] is_a  protein complex
CAF-1 complex (GO:0033186) [is_a relation] is_a  protein complex
CAK-ERCC2 complex (GO:0070516) [is_a relation] is_a  protein complex
calcitonin family receptor complex (GO:1903439) [is_a relation] is_a  protein complex
calcium channel complex (GO:0034704) [is_a relation] is_a  protein complex
calcium- and calmodulin-dependent protein kinase complex (GO:0005954) [is_a relation] is_a  protein complex
calprotectin complex (GO:1990660) [is_a relation] is_a  protein complex
cAMP-dependent protein kinase complex (GO:0005952) [is_a relation] is_a  protein complex
carbamoyl-phosphate synthase complex (GO:0005951) [is_a relation] is_a  protein complex
carbon phosphorus lyase complex (GO:1904176) [is_a relation] is_a  protein complex
carboxy-terminal domain protein kinase complex (GO:0032806) [is_a relation] is_a  protein complex
caspase complex (GO:0008303) [is_a relation] is_a  protein complex
catalytic complex (GO:1902494) [is_a relation] is_a  protein complex
catenin complex (GO:0016342) [is_a relation] is_a  protein complex
catenin-TCF7L2 complex (GO:0071664) [is_a relation] is_a  protein complex
cation channel complex (GO:0034703) [is_a relation] is_a  protein complex
cation-transporting ATPase complex (GO:0090533) [is_a relation] is_a  protein complex
caveolar macromolecular signaling complex (GO:0002095) [is_a relation] is_a  protein complex
Cbf1-Met4-Met28 complex (GO:0089713) [is_a relation] is_a  protein complex
CBF3 complex (GO:0031518) [is_a relation] is_a  protein complex
CBM complex (GO:0032449) [is_a relation] is_a  protein complex
Cbp3p-Cbp6 complex (GO:0061671) [is_a relation] is_a  protein complex
CCR4-NOT complex (GO:0030014) [is_a relation] is_a  protein complex
CCR4-NOT core complex (GO:0030015) [is_a relation] is_a  protein complex
CD19-Vav-PIK3R1 complex (GO:0070024) [is_a relation] is_a  protein complex
CD20-Lck-Fyn complex (GO:0070331) [is_a relation] is_a  protein complex
CD20-Lck-Lyn-Fyn complex (GO:0070332) [is_a relation] is_a  protein complex
Cdc42 GTPase complex (GO:0071521) [is_a relation] is_a  protein complex
Cdc48p-Npl4p-Vms1p AAA ATPase complex (GO:0036266) [is_a relation] is_a  protein complex
Cdc50p-Drs2p complex (GO:1990530) [is_a relation] is_a  protein complex
cell envelope Sec protein transport complex (GO:0031522) [is_a relation] is_a  protein complex
cellulose synthase complex (GO:0010330) [is_a relation] is_a  protein complex
CENP-A recruiting complex (GO:0098654) [is_a relation] is_a  protein complex
centralspindlin complex (GO:0097149) [is_a relation] is_a  protein complex
CFTR-NHERF-ezrin complex (GO:0034662) [is_a relation] is_a  protein complex
CGRP receptor complex (GO:1990406) [is_a relation] is_a  protein complex
chaperone-mediated autophagy translocation complex (GO:0061742) [is_a relation] is_a  protein complex
chaperonin ATPase complex (GO:0016465) [is_a relation] is_a  protein complex
chaperonin-containing T-complex (GO:0005832) [is_a relation] is_a  protein complex
checkpoint clamp complex (GO:0030896) [is_a relation] is_a  protein complex
chloride channel complex (GO:0034707) [is_a relation] is_a  protein complex
chloroplast ATP synthase complex (GO:0009544) [is_a relation] is_a  protein complex
chloroplast outer membrane translocon (GO:0010278) [is_a relation] is_a  protein complex
chloroplast thylakoid membrane protein complex (GO:0098807) [is_a relation] is_a  protein complex
CHOP-ATF3 complex (GO:1990622) [is_a relation] is_a  protein complex
chromatin silencing complex (GO:0005677) [is_a relation] is_a  protein complex
chromosome segregation-directing complex (GO:0043913) [is_a relation] is_a  protein complex
CIA complex (GO:0097361) [is_a relation] is_a  protein complex
ciliary necklace (GO:0097538) [is_a relation] is_a  protein complex
ciliary neurotrophic factor receptor complex (GO:0070110) [is_a relation] is_a  protein complex
ciliary transition fiber (GO:0097539) [is_a relation] is_a  protein complex
citrate lyase complex (GO:0009346) [is_a relation] is_a  protein complex
CKM complex (GO:1990508) [is_a relation] is_a  protein complex
classical-complement-pathway C3/C5 convertase complex (GO:0005601) [is_a relation] is_a  protein complex
clathrin complex (GO:0071439) [is_a relation] is_a  protein complex
CNTFR-CLCF1 complex (GO:0097059) [is_a relation] is_a  protein complex
CoA-synthesizing protein complex (GO:1990143) [is_a relation] is_a  protein complex
CoB-CoM heterodisulfide reductase complex (GO:0044678) [is_a relation] is_a  protein complex
cobalamin transport complex (GO:1990191) [is_a relation] is_a  protein complex
cohesin complex (GO:0008278) [is_a relation] is_a  protein complex
cohesin core heterodimer (GO:0008280) [is_a relation] is_a  protein complex
collagen trimer (GO:0005581) [is_a relation] is_a  protein complex
COMA complex (GO:0000817) [is_a relation] is_a  protein complex
complement component C1 complex (GO:0005602) [is_a relation] is_a  protein complex
complex of collagen trimers (GO:0098644) [is_a relation] is_a  protein complex
condensed chromosome inner kinetochore (GO:0000939) [is_a relation] is_a  protein complex
condensed chromosome outer kinetochore (GO:0000940) [is_a relation] is_a  protein complex
condensin complex (GO:0000796) [is_a relation] is_a  protein complex
condensin core heterodimer (GO:0000797) [is_a relation] is_a  protein complex
connexon complex (GO:0005922) [is_a relation] is_a  protein complex
contractile vacuole pore (GO:0031913) [is_a relation] is_a  protein complex
COP9 signalosome (GO:0008180) [is_a relation] is_a  protein complex
copper ion transmembrane transporter complex (GO:1903113) [is_a relation] is_a  protein complex
core TFIIH complex (GO:0000439) [is_a relation] is_a  protein complex
CORVET complex (GO:0033263) [is_a relation] is_a  protein complex
CRD-mediated mRNA stability complex (GO:0070937) [is_a relation] is_a  protein complex
creatine kinase complex (GO:0002185) [is_a relation] is_a  protein complex
CRLF-CLCF1 complex (GO:0097058) [is_a relation] is_a  protein complex
CSF1-CSF1R complex (GO:1990682) [is_a relation] is_a  protein complex
CSK-GAP-A.p62 complex (GO:0070214) [is_a relation] is_a  protein complex
CSL-Notch-Mastermind transcription factor complex (GO:1990433) [is_a relation] is_a  protein complex
Ctf18 RFC-like complex (GO:0031390) [is_a relation] is_a  protein complex
CUGBP1-eIF2 complex (GO:0071075) [is_a relation] is_a  protein complex
CURI complex (GO:0032545) [is_a relation] is_a  protein complex
CVT complex (GO:0034270) [is_a relation] is_a  protein complex
cyclic-nucleotide phosphodiesterase complex (GO:0005966) [is_a relation] is_a  protein complex
cyclin-dependent protein kinase 5 holoenzyme complex (GO:0016533) [is_a relation] is_a  protein complex
cyclin-dependent protein kinase holoenzyme complex (GO:0000307) [is_a relation] is_a  protein complex
cysteine synthase complex (GO:0009333) [is_a relation] is_a  protein complex
cytochrome b6f complex (GO:0009512) [is_a relation] is_a  protein complex
cytochrome complex (GO:0070069) [is_a relation] is_a  protein complex
cytochrome o ubiquinol oxidase complex (GO:0009319) [is_a relation] is_a  protein complex
cytoplasmic RNA cap binding complex (GO:0034519) [is_a relation] is_a  protein complex
cytosolic tRNA wobble base thiouridylase complex (GO:0002144) [is_a relation] is_a  protein complex
D-amino-acid dehydrogenase complex (GO:0009324) [is_a relation] is_a  protein complex
Dbf4-dependent protein kinase complex (GO:0031431) [is_a relation] is_a  protein complex
DBIRD complex (GO:0044609) [is_a relation] is_a  protein complex
Dcp1-Dcp2 complex (GO:0098745) [is_a relation] is_a  protein complex
death-inducing signaling complex (GO:0031264) [is_a relation] is_a  protein complex
decaprenyl diphosphate synthase complex (GO:0032476) [is_a relation] is_a  protein complex
dehydrodolichyl diphosphate synthase complex (GO:1904423) [is_a relation] is_a  protein complex
Delta1 complex (GO:0070763) [is_a relation] is_a  protein complex
Derlin-1 retrotranslocation complex (GO:0036513) [is_a relation] is_a  protein complex
Derlin-1-VIMP complex (GO:0036502) [is_a relation] is_a  protein complex
DiaA complex (GO:1990125) [is_a relation] is_a  protein complex
diamine N-acetyltransferase complex (GO:1990235) [is_a relation] is_a  protein complex
dihydrolipoyl dehydrogenase complex (GO:0045240) [is_a relation] is_a  protein complex
dimethyl sulfoxide reductase complex (GO:0009390) [is_a relation] is_a  protein complex
divisome complex (GO:1990586) [is_a relation] is_a  protein complex
DNA bending complex (GO:1990104) [is_a relation] is_a  protein complex
DNA helicase complex (GO:0033202) [is_a relation] is_a  protein complex
DNA ligase III-XRCC1 complex (GO:0070421) [is_a relation] is_a  protein complex
DNA ligase IV complex (GO:0032807) [is_a relation] is_a  protein complex
DNA packaging complex (GO:0044815) [is_a relation] is_a  protein complex
DNA polymerase complex (GO:0042575) [is_a relation] is_a  protein complex
DNA polymerase III, clamp loader chi/psi subcomplex (GO:0043847) [is_a relation] is_a  protein complex
DNA polymerase III, clamp loader complex (GO:0043846) [is_a relation] is_a  protein complex
DNA polymerase III, core complex (GO:0044776) [is_a relation] is_a  protein complex
DNA polymerase III, proofreading complex (GO:0043845) [is_a relation] is_a  protein complex
DNA polymerase processivity factor complex (GO:0044796) [is_a relation] is_a  protein complex
DNA recombinase mediator complex (GO:0033061) [is_a relation] is_a  protein complex
DNA repair complex (GO:1990391) [is_a relation] is_a  protein complex
DNA replication factor A complex (GO:0005662) [is_a relation] is_a  protein complex
DNA replication factor C complex (GO:0005663) [is_a relation] is_a  protein complex
DNA replication factor C core complex (GO:0070517) [is_a relation] is_a  protein complex
DNA topoisomerase complex (ATP-hydrolyzing) (GO:0009330) [is_a relation] is_a  protein complex
DNA topoisomerase IV complex (GO:0009340) [is_a relation] is_a  protein complex
DNA-directed RNA polymerase complex (GO:0000428) [is_a relation] is_a  protein complex
DnaB-DnaC complex (GO:1990100) [is_a relation] is_a  protein complex
dolichol-phosphate-mannose synthase complex (GO:0033185) [is_a relation] is_a  protein complex
dolichyl-phosphate-mannose-protein mannosyltransferase complex (GO:0031502) [is_a relation] is_a  protein complex
Dom34-Hbs1 complex (GO:1990533) [is_a relation] is_a  protein complex
Dsl1p complex (GO:0070939) [is_a relation] is_a  protein complex
DUBm complex (GO:0071819) [is_a relation] is_a  protein complex
Dxr protein complex (GO:1990065) [is_a relation] is_a  protein complex
dystrobrevin complex (GO:0016014) [is_a relation] is_a  protein complex
dystroglycan complex (GO:0016011) [is_a relation] is_a  protein complex
dystrophin-associated glycoprotein complex (GO:0016010) [is_a relation] is_a  protein complex
E.F.G complex (GO:0034692) [is_a relation] is_a  protein complex
EARP complex (GO:1990745) [is_a relation] is_a  protein complex
Ecsit-NDUFAF1 complex (GO:0034985) [is_a relation] is_a  protein complex
EFF-1 complex (GO:1990392) [is_a relation] is_a  protein complex
efflux pump complex (GO:1990281) [is_a relation] is_a  protein complex
egasyn-beta-glucuronidase complex (GO:0070385) [is_a relation] is_a  protein complex
EGFR-Grb2-Sos complex (GO:0070620) [is_a relation] is_a  protein complex
EGFR-Shc-Grb2-Sos complex (GO:0070621) [is_a relation] is_a  protein complex
EGO complex (GO:0034448) [is_a relation] is_a  protein complex
eisosome filament (GO:0036286) [is_a relation] is_a  protein complex
EKC/KEOPS complex (GO:0000408) [is_a relation] is_a  protein complex
electron transfer flavoprotein complex (GO:0045251) [is_a relation] is_a  protein complex
Elg1 RFC-like complex (GO:0031391) [is_a relation] is_a  protein complex
Elongator holoenzyme complex (GO:0033588) [is_a relation] is_a  protein complex
endopeptidase Clp complex (GO:0009368) [is_a relation] is_a  protein complex
endoplasmic reticulum chaperone complex (GO:0034663) [is_a relation] is_a  protein complex
endoplasmic reticulum palmitoyltransferase complex (GO:0031211) [is_a relation] is_a  protein complex
endoplasmic reticulum Sec complex (GO:0031205) [is_a relation] is_a  protein complex
endosomal scaffold complex (GO:0032969) [is_a relation] is_a  protein complex
enterobactin synthetase complex (GO:0009366) [is_a relation] is_a  protein complex
enzyme IIA-maltose transporter complex (GO:1990154) [is_a relation] is_a  protein complex
ER membrane insertion complex (GO:0072379) [is_a relation] is_a  protein complex
ER membrane protein complex (GO:0072546) [is_a relation] is_a  protein complex
ERMES complex (GO:0032865) [is_a relation] is_a  protein complex
ESCRT complex (GO:0036452) [is_a relation] is_a  protein complex
ethanolamine ammonia-lyase complex (GO:0009350) [is_a relation] is_a  protein complex
eukaryotic translation elongation factor 1 complex (GO:0005853) [is_a relation] is_a  protein complex
eukaryotic translation initiation factor 2 complex (GO:0005850) [is_a relation] is_a  protein complex
eukaryotic translation initiation factor 2B complex (GO:0005851) [is_a relation] is_a  protein complex
eukaryotic translation initiation factor 3 complex (GO:0005852) [is_a relation] is_a  protein complex
eukaryotic translation initiation factor 4F complex (GO:0016281) [is_a relation] is_a  protein complex
excinuclease repair complex (GO:0009380) [is_a relation] is_a  protein complex
exocyst (GO:0000145) [is_a relation] is_a  protein complex
exodeoxyribonuclease V complex (GO:0009338) [is_a relation] is_a  protein complex
exodeoxyribonuclease VII complex (GO:0009318) [is_a relation] is_a  protein complex
exomer complex (GO:0034044) [is_a relation] is_a  protein complex
exon-exon junction complex (GO:0035145) [is_a relation] is_a  protein complex
exosome (RNase complex) (GO:0000178) [is_a relation] is_a  protein complex
extracellular exosome complex (GO:1990563) [is_a relation] is_a  protein complex
F-actin capping protein complex (GO:0008290) [is_a relation] is_a  protein complex
FAL1-SGD1 complex (GO:0097078) [is_a relation] is_a  protein complex
FANCM-MHF complex (GO:0071821) [is_a relation] is_a  protein complex
Fanconi anaemia nuclear complex (GO:0043240) [is_a relation] is_a  protein complex
FAR/SIN/STRIPAK complex (GO:0090443) [is_a relation] is_a  protein complex
fatty acid beta-oxidation multienzyme complex (GO:0036125) [is_a relation] is_a  protein complex
fatty acid elongase complex (GO:0009923) [is_a relation] is_a  protein complex
fatty acid synthase complex (GO:0005835) [is_a relation] is_a  protein complex
fatty-acyl-CoA synthase complex (GO:0005836) [is_a relation] is_a  protein complex
Fc receptor complex (GO:0032997) [is_a relation] is_a  protein complex
ferredoxin hydrogenase complex (GO:0009375) [is_a relation] is_a  protein complex
ferredoxin:thioredoxin reductase complex (GO:0030386) [is_a relation] is_a  protein complex
ferritin complex (GO:0070288) [is_a relation] is_a  protein complex
FHF complex (GO:0070695) [is_a relation] is_a  protein complex
fibrinogen complex (GO:0005577) [is_a relation] is_a  protein complex
fibronectin-tissue transglutaminase complex (GO:0071078) [is_a relation] is_a  protein complex
filamentous actin (GO:0031941) [is_a relation] is_a  protein complex
flotillin complex (GO:0016600) [is_a relation] is_a  protein complex
FMN reductase complex (GO:1990202) [is_a relation] is_a  protein complex
follicle-stimulating hormone complex (GO:0016914) [is_a relation] is_a  protein complex
formate dehydrogenase complex (GO:0009326) [is_a relation] is_a  protein complex
formyl-methanofuran dehydrogenase (molybdenum enzyme) complex (GO:0044676) [is_a relation] is_a  protein complex
formyl-methanofuran dehydrogenase (tungsten enzyme) complex (GO:0044675) [is_a relation] is_a  protein complex
fumarate reductase complex (GO:0045283) [is_a relation] is_a  protein complex
G-protein alpha(13)-synembrin complex (GO:0071155) [is_a relation] is_a  protein complex
G-protein alpha(i)1-synembrin complex (GO:0071154) [is_a relation] is_a  protein complex
G-protein alpha(o)-synembrin complex (GO:0071153) [is_a relation] is_a  protein complex
G-protein alpha(q)-synembrin complex (GO:0071152) [is_a relation] is_a  protein complex
G-protein beta/gamma-Btk complex (GO:0070441) [is_a relation] is_a  protein complex
G-protein beta/gamma-Raf-1 complex (GO:0070422) [is_a relation] is_a  protein complex
G-protein beta/gamma-subunit complex (GO:0031680) [is_a relation] is_a  protein complex
G-protein coupled GABA receptor complex (GO:1902712) [is_a relation] is_a  protein complex
GABA receptor complex (GO:1902710) [is_a relation] is_a  protein complex
GABA-A receptor complex (GO:1902711) [is_a relation] is_a  protein complex
GAIT complex (GO:0097452) [is_a relation] is_a  protein complex
galectin complex (GO:1990724) [is_a relation] is_a  protein complex
gamma-secretase complex (GO:0070765) [is_a relation] is_a  protein complex
gamma-secretase-Delta1 complex (GO:0070764) [is_a relation] is_a  protein complex
gamma-tubulin complex (GO:0000930) [is_a relation] is_a  protein complex
GARP complex (GO:0000938) [is_a relation] is_a  protein complex
GATA1-TAL1-TCF3-Lmo2 complex (GO:0070353) [is_a relation] is_a  protein complex
GATA2-TAL1-TCF3-Lmo2 complex (GO:0070354) [is_a relation] is_a  protein complex
GATOR2 complex (GO:0061700) [is_a relation] is_a  protein complex
GCH1 complex (GO:0034615) [is_a relation] is_a  protein complex
Gemin3-Gemin4-Gemin5 complex (GO:0034716) [is_a relation] is_a  protein complex
Gemin6-Gemin7-unrip complex (GO:0034717) [is_a relation] is_a  protein complex
GET complex (GO:0043529) [is_a relation] is_a  protein complex
GID complex (GO:0034657) [is_a relation] is_a  protein complex
GLI-SUFU complex (GO:1990788) [is_a relation] is_a  protein complex
glucose-1-phosphate adenylyltransferase complex (GO:0010170) [is_a relation] is_a  protein complex
glucosidase complex (GO:1902687) [is_a relation] is_a  protein complex
glucosidase II complex (GO:0017177) [is_a relation] is_a  protein complex
glutamate decarboxylase complex (GO:1902793) [is_a relation] is_a  protein complex
glutamate dehydrogenase complex (GO:1990148) [is_a relation] is_a  protein complex
glutamate synthase complex (GO:0031026) [is_a relation] is_a  protein complex
glutamate synthase complex (NADH) (GO:0031027) [is_a relation] is_a  protein complex
glutamate synthase complex (NADPH) (GO:0009342) [is_a relation] is_a  protein complex
glutamate-cysteine ligase complex (GO:0017109) [is_a relation] is_a  protein complex
glutamate-tRNA ligase complex (GO:0009332) [is_a relation] is_a  protein complex
glutaminase complex (GO:1903600) [is_a relation] is_a  protein complex
glutamyl-tRNA(Gln) amidotransferase complex (GO:0030956) [is_a relation] is_a  protein complex
glutathione hydrolase complex (GO:0061672) [is_a relation] is_a  protein complex
glutathione synthase complex (GO:0036087) [is_a relation] is_a  protein complex
glycerol-3-phosphate dehydrogenase complex (GO:0009331) [is_a relation] is_a  protein complex
glycine cleavage complex (GO:0005960) [is_a relation] is_a  protein complex
glycine reductase complex (GO:0030700) [is_a relation] is_a  protein complex
glycine-tRNA ligase complex (GO:0009345) [is_a relation] is_a  protein complex
glycolate oxidase complex (GO:0009339) [is_a relation] is_a  protein complex
glycoprotein complex (GO:0090665) [is_a relation] is_a  protein complex
glycosylphosphatidylinositol-mannosyltransferase I complex (GO:1990529) [is_a relation] is_a  protein complex
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (GO:0000506) [is_a relation] is_a  protein complex
GMP reductase complex (GO:1902560) [is_a relation] is_a  protein complex
Golgi transport complex (GO:0017119) [is_a relation] is_a  protein complex
GPI-anchor transamidase complex (GO:0042765) [is_a relation] is_a  protein complex
granulocyte macrophage colony-stimulating factor receptor complex (GO:0030526) [is_a relation] is_a  protein complex
Grb2-EGFR complex (GO:0070436) [is_a relation] is_a  protein complex
Grb2-Shc complex (GO:0070437) [is_a relation] is_a  protein complex
Grb2-SHP-2 complex (GO:0070720) [is_a relation] is_a  protein complex
Grb2-Sos complex (GO:0070618) [is_a relation] is_a  protein complex
growth factor complex (GO:0036454) [is_a relation] is_a  protein complex
GTPase activator complex (GO:1902773) [is_a relation] is_a  protein complex
Gtr1-Gtr2 GTPase complex (GO:1990131) [is_a relation] is_a  protein complex
guanyl-nucleotide exchange factor complex (GO:0032045) [is_a relation] is_a  protein complex
guanylate cyclase complex, soluble (GO:0008074) [is_a relation] is_a  protein complex
H-gal-GP complex (GO:1990850) [is_a relation] is_a  protein complex
H-NS-Cnu complex (GO:0036411) [is_a relation] is_a  protein complex
H-NS-Hha complex (GO:0097495) [is_a relation] is_a  protein complex
H3 histone acetyltransferase complex (GO:0070775) [is_a relation] is_a  protein complex
H4 histone acetyltransferase complex (GO:1902562) [is_a relation] is_a  protein complex
H4/H2A histone acetyltransferase complex (GO:0043189) [is_a relation] is_a  protein complex
haptoglobin-hemoglobin complex (GO:0031838) [is_a relation] is_a  protein complex
HCN channel complex (GO:0098855) [is_a relation] is_a  protein complex
Hedgehog signaling complex (GO:0035301) [is_a relation] is_a  protein complex
hemidesmosome associated protein complex (GO:0098733) [is_a relation] is_a  protein complex
hemoglobin complex (GO:0005833) [is_a relation] is_a  protein complex
heparanase complex (GO:1904974) [is_a relation] is_a  protein complex
heterotrimeric G-protein complex (GO:0005834) [is_a relation] is_a  protein complex
HICS complex (GO:0044697) [is_a relation] is_a  protein complex
high-affinity iron permease complex (GO:0033573) [is_a relation] is_a  protein complex
HIR complex (GO:0000417) [is_a relation] is_a  protein complex
histamine-gated chloride channel complex (GO:0019183) [is_a relation] is_a  protein complex
histone acetyltransferase complex (GO:0000123) [is_a relation] is_a  protein complex
histone deacetylase complex (GO:0000118) [is_a relation] is_a  protein complex
histone H3-K14 acetyltransferase complex (GO:0036409) [is_a relation] is_a  protein complex
histone methyltransferase complex (GO:0035097) [is_a relation] is_a  protein complex
Holliday junction resolvase complex (GO:0048476) [is_a relation] is_a  protein complex
HOPS complex (GO:0030897) [is_a relation] is_a  protein complex
HSP90-CDC37 chaperone complex (GO:1990565) [is_a relation] is_a  protein complex
hydrogen:potassium-exchanging ATPase complex (GO:0005889) [is_a relation] is_a  protein complex
i-AAA complex (GO:0031942) [is_a relation] is_a  protein complex
I-kappaB/NF-kappaB complex (GO:0033256) [is_a relation] is_a  protein complex
Ig heavy chain-bound endoplasmic reticulum chaperone complex (GO:0034664) [is_a relation] is_a  protein complex
IkappaB kinase complex (GO:0008385) [is_a relation] is_a  protein complex
IKKalpha-IKKalpha complex (GO:0038059) [is_a relation] is_a  protein complex
imidazoleglycerol-phosphate synthase complex (GO:0009382) [is_a relation] is_a  protein complex
Iml1 complex (GO:1990130) [is_a relation] is_a  protein complex
immunoglobulin complex (GO:0019814) [is_a relation] is_a  protein complex
INA complex (GO:1990524) [is_a relation] is_a  protein complex
inaD signaling complex (GO:0016027) [is_a relation] is_a  protein complex
inflammasome complex (GO:0061702) [is_a relation] is_a  protein complex
inhibin complex (GO:0043511) [is_a relation] is_a  protein complex
inhibin-betaglycan-ActRII complex (GO:0034673) [is_a relation] is_a  protein complex
inner mitochondrial membrane protein complex (GO:0098800) [is_a relation] is_a  protein complex
inositol phosphoceramide synthase complex (GO:0070916) [is_a relation] is_a  protein complex
insulin receptor complex (GO:0005899) [is_a relation] is_a  protein complex
integrator complex (GO:0032039) [is_a relation] is_a  protein complex
integrin complex (GO:0008305) [is_a relation] is_a  protein complex
interferon regulatory factor complex (GO:0097071) [is_a relation] is_a  protein complex
interleukin-1 receptor complex (GO:0045323) [is_a relation] is_a  protein complex
interleukin-12 complex (GO:0043514) [is_a relation] is_a  protein complex
interleukin-12 receptor complex (GO:0042022) [is_a relation] is_a  protein complex
interleukin-12-interleukin-12 receptor complex (GO:0070023) [is_a relation] is_a  protein complex
interleukin-13 receptor complex (GO:0005898) [is_a relation] is_a  protein complex
interleukin-18 receptor complex (GO:0045092) [is_a relation] is_a  protein complex